Evidence map›Paper›PMID 38992254›Full record

ArticleNature immunology2024

Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8

Yuanyuan You, Josefine Dunst, Kewei Ye, Patrick A Sandoz, Annika Reinhardt, Inga Sandrock, Natalia R Comet, Rupak Dey Sarkar, Emily Yang, Estelle Duprez and 8 more

Abstract read
In one paragraph

Article in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Design principles for integrated AI alignment.Patterns (New York, N.Y.) · 2026
    Review
  3. Article
  4. Thymic Dendritic Cells Revisited.Immunological reviews · 2025
    Review
  5. Article
  6. Article
  7. Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025
    Review
  8. Sterile production of interferons in the thymus.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yuanyuan You *Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Josefine Dunst *Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Kewei YeDivision of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Patrick A SandozDepartment of Applied Physics, Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-8379-7267
Annika ReinhardtDivision of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Inga SandrockInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Natalia R CometCenter for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Rupak Dey SarkarMax Planck Research Group, Würzburg Institute of Systems Immunology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.ORCID http://orcid.org/0009-0008-0203-5772
Emily YangDepartment of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-6028-2455
Estelle DuprezEpigenetic Factors in Normal and Malignant Hematopoiesis Lab, CRCM, CNRS, INSERM, Institut Paoli Calmettes, Aix Marseille University, Marseille, France.ORCID http://orcid.org/0000-0003-3810-5740
Judith AgudoDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
Brian D BrownThe Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-3670-8778
Paul J UtzDepartment of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-1181-1565
Wolfgang KastenmüllerMax Planck Research Group, Würzburg Institute of Systems Immunology, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-3835-1485
Carmen GerlachCenter for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-7889-2393
Immo PrinzInstitute of Immunology, Hannover Medical School, Hannover, Germany.
Björn ÖnfeltDepartment of Applied Physics, Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-5178-7593
Taras KreslavskyDivision of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. taras.kreslavskiy@ki.se.ORCID http://orcid.org/0000-0002-6672-1914

Funding

Barncancerfonden (Swedish Childhood Cancer Foundation) PR2021-017Barncancerfonden (Swedish Childhood Cancer Foundation) PR2023-0091Cancerfonden (Swedish Cancer Society) 21 1602 PjDeutsche Forschungsgemeinschaft (German Research Foundation) DU 1964/1-1Radiumhemmets Forskningsfonder (Cancer Research Foundations of Radiumhemmet) 211192Radiumhemmets Forskningsfonder (Cancer Research Foundations of Radiumhemmet) 231233
6 · The paper itself

Abstract

Upregulation of diverse self-antigens that constitute components of the inflammatory response overlaps spatially and temporally with the emergence of pathogen-derived foreign antigens. Therefore, discrimination between these inflammation-associated self-antigens and pathogen-derived molecules represents a unique challenge for the adaptive immune system. Here, we demonstrate that CD8

Indexed as

Antigen PresentationAutoantigensCD8-Positive T-LymphocytesInflammationThymocytesThymus GlandAnimalsAutoimmunityEosinophilsImmune ToleranceImmunity, InnateLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicAutoantigens

Identifiers

PMID38992254
PMCPMC11291280

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.