Evidence map›Paper›PMID 38992155›Full record

ArticlePediatric research2024

Brain gray matter changes in children at risk for sudden unexpected death in epilepsy.

Bhaswati Roy, Jennifer A Ogren, Luke A Allen, Beate Diehl, Raman Sankar, Samden D Lhatoo, Rajesh Kumar, Ronald M Harper

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bhaswati RoyDepartment of Anesthesiology and Perioperative Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Jennifer A OgrenDepartment of Neurobiology, University of California at Los Angeles, Los Angeles, CA, 90095, USA.
Luke A AllenDepartment of Clinical and Experimental Epilepsy, University College London Institute of Neurology, London, UK.
Beate DiehlDepartment of Clinical and Experimental Epilepsy, University College London Institute of Neurology, London, UK.
Raman SankarDepartment of Neurology and Pediatrics, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Samden D LhatooDepartment of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Rajesh KumarDepartment of Anesthesiology and Perioperative Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA. rkumar@mednet.ucla.edu.
Ronald M HarperDepartment of Neurobiology, University of California at Los Angeles, Los Angeles, CA, 90095, USA.

Funding

Brain Changes in Pediatric Obstructive Sleep ApneaR21HD102544 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH · 2021 to 2022
$429k
Brain Metabolites, Brain Antioxidant, and Cerebral Blood Flow Deficits in Single Ventricle Heart DiseaseR21NS131850 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUMAR, RAJESH, PIKE, NANCY ANN · 2023 to 2024
$429k
NICHD NIH HHS R21 HD102544NINDS NIH HHS R21 NS131850
6 · The paper itself

Abstract

backgroundPotential failing adult brain sites, stratified by risk, mediating Sudden Unexpected Death in Epilepsy (SUDEP) have been described, but are unknown in children.

methodsWe examined regional brain volumes using T1-weighted MRI images in 21 children with epilepsy at high SUDEP risk and 62 healthy children, together with SUDEP risk scores, calculated from focal seizure frequency. Gray matter tissue type was partitioned, maps normalized, smoothed, and compared between groups (SPM12; ANCOVA; covariates, age, sex, and BMI). Partial correlations between regional volumes and seizure frequency were examined (SPM12, covariates, age, sex, and BMI); 67% were at high risk for SUDEP.

resultsThe cerebellar cortex, hippocampus, amygdala, putamen, cingulate, thalamus, and para-hippocampal gyrus showed increased gray matter volumes in epilepsy, and decreased volumes in the posterior thalamus, lingual gyrus, and temporal cortices. The cingulate, insula, and putamen showed significant positive relationships with focal seizure frequency indices using whole-brain voxel-by-voxel partial correlations. Tissue volume changes in selected sites differed in direction from adults; particularly, cerebellar sites, key for hypotensive recovery, increased rather than adult declines.

conclusionThe volume increases may represent expansion by inflammatory or other processes that, with sustained repetitive seizure discharge, lead to tissue volume declines described earlier in adults. IMPACT: Children with epilepsy, who are at risk for Sudden Unexplained Death, show changes in brain volume that often differ in direction of change from adults at risk for SUDEP. Sites of volume change play significant roles in mediating breathing and blood pressure, and include areas that serve recovery from prolonged apnea and marked loss of blood pressure. The extent of volume changes correlated with focal seizure frequency. Although the underlying processes contributing to regional volume changes remain speculative, regions of tissue swelling in pediatric brain areas may represent transitory conditions that later lead to tissue loss in the adult condition.

Indexed as

BrainEpilepsyGray MatterSudden Unexpected Death in EpilepsyAdolescentCase-Control StudiesChildChild, PreschoolFemaleHumansMagnetic Resonance ImagingMaleOrgan SizeRisk Factors

Identifiers

PMID38992155
PMCPMC11772226

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.