Evidence map›Paper›PMID 38992070›Full record

ArticleScientific reports2024

Anadenanthera colubrina regulated LPS-induced inflammation by suppressing NF-κB and p38-MAPK signaling pathways.

Carolina Medeiros de Almeida Maia, Priscilla Guimarães Silva Vasconcelos, Silvana Pasetto, Walton Colby Godwin, Joanda Paolla Raimundo E Silva, Josean Fechine Tavares, Vanessa Pardi, Edja Maria Melo de Brito Costa, Ramiro Mendonça Murata

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Green Synthesis of Silver Nanoparticle fromAntibiotics (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carolina Medeiros de Almeida MaiaDepartment of Dentistry, Postgraduate Program in Dentistry, State University of Paraiba, Campina Grande, Paraiba, Brazil.
Priscilla Guimarães Silva VasconcelosDepartment of Dentistry, Postgraduate Program in Dentistry, State University of Paraiba, Campina Grande, Paraiba, Brazil.
Silvana PasettoDepartment of Biology, East Carolina University, Greenville, NC, USA.
Walton Colby GodwinDepartment of Foundational Sciences, School of Dental Medicine, East Carolina University, Greenville, NC, USA.
Joanda Paolla Raimundo E SilvaPostgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, João Pessoa, Paraiba, Brazil.
Josean Fechine TavaresPostgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, João Pessoa, Paraiba, Brazil.
Vanessa PardiDepartment of Foundational Sciences, School of Dental Medicine, East Carolina University, Greenville, NC, USA.
Edja Maria Melo de Brito CostaDepartment of Dentistry, Postgraduate Program in Dentistry, State University of Paraiba, Campina Grande, Paraiba, Brazil. edjacosta@gmail.com.
Ramiro Mendonça MurataDepartment of Foundational Sciences, School of Dental Medicine, East Carolina University, Greenville, NC, USA. muratar16@ecu.edu.

Funding

Candida-Host interactions: impact on the host pro- and anti-viral restrictions factorsR03DE031190 · NIDCR · EAST CAROLINA UNIVERSITY · PI MURATA, RAMIRO MENDONCA · 2021 to 2022
$302k
Brazilian Coordination of Improvement of Higher Education Personnel PDSE-Call 47/2017National Institutes of Health-NIH R03DE031190NIDCR NIH HHS R03 DE031190
6 · The paper itself

Abstract

We aimed to determine the chemical profile and unveil Anadenanthera colubrina (Vell.) Brenan standardized extract effects on inflammatory cytokines expression and key proteins from immunoregulating signaling pathways on LPS-induced THP-1 monocyte. Using the RT-PCR and Luminex Assays, we planned to show the gene expression and the levels of IL-8, IL-1β, and IL-10 inflammatory cytokines. Key proteins of NF-κB and MAPK transduction signaling pathways (NF-κB, p-38, p-NF-κB, and p-p38) were detected by Simple Western. Using HPLC-ESI-MS

Indexed as

InflammationLipopolysaccharidesMAP Kinase Signaling SystemNF-kappa Bp38 Mitogen-Activated Protein KinasesPlant ExtractsCell SurvivalCytokinesFabaceaeHumansNF-kappa B p50 SubunitSignal TransductionTHP-1 CellsCytokinesLipopolysaccharidesNF-kappa BNF-kappa B p50 SubunitNFKB1 protein, humanp38 Mitogen-Activated Protein KinasesPlant ExtractsAnti-inflammatory agentsCytokinesImmune responseInflammatoryPhytotherapyPolyphenolsTLR4 receptor

Identifiers

PMID38992070
PMCPMC11239917

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.