Evidence map›Paper›PMID 38992033›Full record

ArticleNature communications2024

Precision arbovirus serology with a pan-arbovirus peptidome.

William R Morgenlander, Wan Ni Chia, Beatriz Parra, Daniel R Monaco, Izabela Ragan, Carlos A Pardo, Richard Bowen, Diana Zhong, Douglas E Norris, Ingo Ruczinski and 4 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Zika virus: an overview update.Current opinion in HIV and AIDS · 2025
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

William R MorgenlanderDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-7205-3732
Wan Ni ChiaProgram in Emerging Infectious Diseases Duke-NUS Medical School, Singapore, Singapore.ORCID 0000-0001-7287-694X
Beatriz ParraDepartment of Microbiology, Universidad del Valle, Cali, Colombia.
Daniel R MonacoDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Izabela RaganDepartment of Biomedical Sciences, Colorado State University College of Veterinary and Biomedical Sciences, Fort Collins, CO, USA.
Carlos A PardoDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-4128-5335
Richard BowenDepartment of Biomedical Sciences, Colorado State University College of Veterinary and Biomedical Sciences, Fort Collins, CO, USA.
Diana ZhongDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-7487-7698
Douglas E NorrisDepartment of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-4631-2777
Ingo RuczinskiDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Anna DurbinDepartment of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-6652-2851
Lin-Fa WangProgram in Emerging Infectious Diseases Duke-NUS Medical School, Singapore, Singapore.ORCID 0000-0003-2752-0535
H Benjamin LarmanDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. hlarman1@jhmi.edu.ORCID 0000-0001-7863-196X
Matthew L RobinsonDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. mrobin85@jhmi.edu.ORCID 0000-0003-0376-8560

Funding

LC: HIV Prevention Trials Network - Laboratory Support for the SARS-CoV-2 Seroprevalence Study (CoVPN 5002)UM1AI068613 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SUSAN H ESHLEMAN, Mark A Marzinke · 2011 to 2026
$100.2M
RESEARCH TRAINING IN MICROBIAL DISEASEST32AI007291 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JOEL N BLANKSON, Sara Elizabeth Cosgrove · 1986 to 2026
$9.1M
Design and Analysis of Displayed PeptidomesR01GM136724 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI LARMAN, HARRY BENJAMIN, RUCZINSKI, INGO · 2020 to 2023
$1.9M
Emerging Neuroviruses and Neurological Inflammatory DiseasesR01NS110122 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PARDO-VILLAMIZAR, CARLOS A · 2019 to 2023
$1.7M
MOH | National Medical Research Council (NMRC) OFLCG19May-0034NIAID NIH HHS T32 AI007291NIAID NIH HHS UM1 AI068613NIGMS NIH HHS R01 GM136724NINDS NIH HHS R01 NS110122U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01 NS110122, R01 GM136724, T32 AI007291U.S. Department of State (United States Department of State) Fulbright Visiting Research Scholarship
6 · The paper itself

Abstract

Arthropod-borne viruses represent a crucial public health threat. Current arboviral serology assays are either labor intensive or incapable of distinguishing closely related viruses, and many zoonotic arboviruses that may transition to humans lack any serologic assays. In this study, we present a programmable phage display platform, ArboScan, that evaluates antibody binding to overlapping peptides that represent the proteomes of 691 human and zoonotic arboviruses. We confirm that ArboScan provides detailed antibody binding information from animal sera, human sera, and an arthropod blood meal. ArboScan identifies distinguishing features of antibody responses based on exposure history in a Colombian cohort of Zika patients. Finally, ArboScan details epitope level information that rapidly identifies candidate epitopes with potential protective significance. ArboScan thus represents a resource for characterizing human and animal arbovirus antibody responses at cohort scale.

Indexed as

Antibodies, ViralArbovirusesAnimalsArbovirus InfectionsCell Surface Display TechniquesColombiaEpitopesFemaleHumansMalePeptide LibraryPeptidesProteomeSerologic TestsZika VirusZika Virus InfectionAntibodies, ViralEpitopesPeptide LibraryPeptidesProteome

Identifiers

PMID38992033
PMCPMC11239951

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.