Evidence map›Paper›PMID 38992020›Full record

ArticleNature communications2024

White-light activatable organic NIR-II luminescence nanomaterials for imaging-guided surgery.

Chunbin Li, Jian Du, Guoyu Jiang, Jianye Gong, Yue Zhang, Mengfan Yao, Jianguo Wang, Limin Wu, Ben Zhong Tang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chunbin Li *College of Chemistry and Chemical Engineering, College of Energy Material and Chemistry, Inner Mongolia Key Laboratory of Fine Organic Synthesis, Inner Mongolia University, Hohhot, 010021, China.
Jian Du *Department of Urology, The First Affiliated Hospital of Shandong First Medical University, Jinan, 250000, Shandong, China.
Guoyu Jiang *College of Chemistry and Chemical Engineering, College of Energy Material and Chemistry, Inner Mongolia Key Laboratory of Fine Organic Synthesis, Inner Mongolia University, Hohhot, 010021, China.
Jianye GongCollege of Chemistry and Chemical Engineering, College of Energy Material and Chemistry, Inner Mongolia Key Laboratory of Fine Organic Synthesis, Inner Mongolia University, Hohhot, 010021, China.
Yue ZhangCollege of Chemistry and Chemical Engineering, College of Energy Material and Chemistry, Inner Mongolia Key Laboratory of Fine Organic Synthesis, Inner Mongolia University, Hohhot, 010021, China.
Mengfan YaoCollege of Chemistry and Chemical Engineering, College of Energy Material and Chemistry, Inner Mongolia Key Laboratory of Fine Organic Synthesis, Inner Mongolia University, Hohhot, 010021, China.
Jianguo WangCollege of Chemistry and Chemical Engineering, College of Energy Material and Chemistry, Inner Mongolia Key Laboratory of Fine Organic Synthesis, Inner Mongolia University, Hohhot, 010021, China. wangjg@iccas.ac.cn.
Limin WuCollege of Chemistry and Chemical Engineering, College of Energy Material and Chemistry, Inner Mongolia Key Laboratory of Fine Organic Synthesis, Inner Mongolia University, Hohhot, 010021, China. wlm@imu.edu.cn.
Ben Zhong TangSchool of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Shenzhen, 518172, Guangdong, China.ORCID 0000-0002-0293-964X

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22165020National Natural Science Foundation of China (National Science Foundation of China) 52033003
6 · The paper itself

Abstract

While second near-infrared (NIR-II) fluorescence imaging is a promising tool for real-time surveillance of surgical operations, the previously reported organic NIR-II luminescent materials for in vivo imaging are predominantly activated by expensive lasers or X-ray with high power and poor illumination homogeneity, which significantly limits their clinical applications. Here we report a white-light activatable NIR-II organic imaging agent by taking advantages of the strong intramolecular/intermolecular D-A interactions of conjugated Y6CT molecules in nanoparticles (Y6CT-NPs), with the brightness of as high as 13315.1, which is over two times that of the brightest laser-activated NIR-II organic contrast agents reported thus far. Upon white-light activation, Y6CT-NPs can achieve not only in vivo imaging of hepatic ischemia reperfusion, but also real-time monitoring of kidney transplantation surgery. During the surgery, identification of the renal vasculature, post-reconstruction assessment of renal allograft vascular integrity, and blood supply analysis of the ureter can be vividly depicted by using Y6CT-NPs with high signal-to-noise ratios upon clinical laparoscopic LED white-light activation. Our work provides efficient molecular design guidelines towards white-light activatable imaging agent and highlights an opportunity for precision imaging theranostics.

Indexed as

Optical ImagingSurgery, Computer-AssistedAnimalsContrast MediaHumansInfrared RaysKidneyKidney TransplantationLightLiverLuminescenceMaleMiceNanoparticlesNanostructuresSpectroscopy, Near-InfraredContrast Media

Identifiers

PMID38992020
PMCPMC11239823

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.