ArticleNature communications2024
Cell atlas of the regenerating human liver after portal vein embolization.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Liver sinusoidal endothelial cells in liver diseases and hepatocellular carcinoma: molecular mechanisms, physiology, and therapies.Molecular biomedicine · 2026Review
- Leveraging IGF signaling to improve the spatial organization and regenerative potential of iPSC-derived vascularized liver organoids.Science advances · 2026Article
- Unleashing innovative cross-organ fibrosis therapies by harnessing the omics revolution.JCI insight · 2026Review
- In vivo visualization of bioactive iron and oxygen using LiON, the labile iron and oxygen notifier.Cell reports methods · 2026Article
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- Towards a reference cell atlas of liver diversity over the human lifespan.Nature reviews. Gastroenterology & hepatology · 2026Review
- Dynamic activation and dual roles of SOX9Frontiers in cell and developmental biology · 2026Article
- Liver regeneration: unraveling the molecular mechanisms and clinical application.Journal of translational medicine · 2025Review
- Multi-omics analysis reveals distinct gene regulatory mechanisms between primary and organoid-derived human hepatocytes.Disease models & mechanisms · 2025Article
- An organotypic atlas of human vascular cells.Nature medicine · 2024Article
- SILAC-Based Characterization of Plasma-Derived Extracellular Vesicles in Patients Undergoing Partial Hepatectomy.International journal of molecular sciences · 2024Article
- Development of a hepatic cryoinjury model to study liver regeneration.Development (Cambridge, England) · 2024Article
- Development of a hepatic cryoinjury model to study liver regeneration.bioRxiv : the preprint server for biology · 2024Article
- Liver specification of human iPSC-derived endothelial cells transplanted into mouse liver.JHEP reports : innovation in hepatology · 2024Article
- Yolk sac cell atlas reveals multiorgan functions during human early development.Science (New York, N.Y.) · 2023Article
- Transcriptomic Profile of the Mouse Postnatal Liver Development by Single-Nucleus RNA Sequencing.Frontiers in cell and developmental biology · 2022Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
The liver has the remarkable capacity to regenerate. In the clinic, regeneration is induced by portal vein embolization, which redirects portal blood flow, resulting in liver hypertrophy in locations with increased blood supply, and atrophy of embolized segments. Here, we apply single-cell and single-nucleus transcriptomics on healthy, hypertrophied, and atrophied patient-derived liver samples to explore cell states in the regenerating liver. Our data unveils pervasive upregulation of genes associated with developmental processes, cellular adhesion, and inflammation in post-portal vein embolization liver, disrupted portal-central hepatocyte zonation, and altered cell subtype composition of endothelial and immune cells. Interlineage crosstalk analysis reveals mesenchymal cells as an interaction hub between immune and endothelial cells, and highlights the importance of extracellular matrix proteins in liver regeneration. Moreover, we establish tissue-scale iterative indirect immunofluorescence imaging for high-dimensional spatial analysis of perivascular microenvironments, uncovering changes to tissue architecture in regenerating liver lobules. Altogether, our data is a rich resource revealing cellular and histological changes in human liver regeneration.
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Registered trials
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