Evidence map›Paper›PMID 38991999›Full record

ArticleNutrition & diabetes2024

The relationship between follicle-stimulating hormone and metabolic dysfunction-associated fatty liver disease in men.

Dong-Hua Bin, Fang Liu, Ke-Ping Peng, Min Zhan, Yan Tan, Qiao Liu, Wang Tang, Zeng-Nan Mo, Xiong-Jun Peng, Gui-Xiang Tian

Abstract read
In one paragraph

Article in Nutrition & diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dong-Hua Bin *Department of Anus and Intesine, The First Hospital of Hunan University of Chinese Medicine, Changsha, China.
Fang Liu *Department of Ultrasoud, The First Hospital of Hunan University of Chinese Medicine, Changsha, China.
Ke-Ping Peng *Department of Otorhinolaryngology-Head and Neck surgery, The first Hospital, Hunan University of Chinese Medicine, Changsha, China.
Min ZhanDepartment of Anus and Intesine, The First Hospital of Hunan University of Chinese Medicine, Changsha, China.
Yan TanDepartment of Ultrasoud, The Second Xiangya Hospital, Central South University, Changsha, China.
Qiao LiuDepartment of Ultrasoud, The Second Xiangya Hospital, Central South University, Changsha, China.
Wang TangDepartment of Ultrasoud, The Second Xiangya Hospital, Central South University, Changsha, China.
Zeng-Nan MoCentre for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, China.
Xiong-Jun PengDepartment of Medical Equipment, The Second Xiangya Hospital, Central South University, Changsha, China. pengxj5284@csu.edu.cn.
Gui-Xiang TianDepartment of Ultrasoud, The Second Xiangya Hospital, Central South University, Changsha, China. tianguixiang@csu.edu.cn.ORCID 0000-0001-6282-269X

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82002397
6 · The paper itself

Abstract

objectivesThe present study aimed to investigate the relationship between male hormones and metabolic dysfunction-associated fatty liver disease (MAFLD) in males.

methodsData from the Fangchenggang Area Male Health and Examination Survey (FAMHES) were used to analyze the male hormone levels between MAFLD patients and controls. Univariate and multivariate logistic regression analyses were performed to identify risk factors for MAFLD. Receiver operating characteristic curve analysis was used to assess the diagnostic performance of male hormones for MAFLD.

resultA total of 1578 individuals were included, with 482 individuals (30.54%) of MAFLD, including 293 (18.57%) with mild disease and 189 (11.98%) with moderate-to-severe disease. The MAFLD patients were significantly older than those without MAFLD. The LH, FSH, and SHBG levels in the MAFLD patients were significantly greater than those in the control group. Age, FSH, LH, SHBG, and estradiol were all risk factors for MAFLD. Age, FSH, and LH were risk factors for moderate-to-severe MAFLD. FSH was an independent risk factor for MAFLD and moderate-to-severe MAFLD. FSH showed an excellent diagnostic value, with an AUC of 0.992 alone and 0.996 after adjusting age.

conclusionsOur findings indicate that FSH may be a potential diagnostic and predictive biomarker for MAFLD.

Indexed as

Follicle Stimulating HormoneLuteinizing HormoneSex Hormone-Binding GlobulinAdultAgedBiomarkersCase-Control StudiesChinaEstradiolFatty LiverHumansMaleMiddle AgedNon-alcoholic Fatty Liver DiseaseRisk FactorsROC CurveBiomarkersEstradiolFollicle Stimulating HormoneLuteinizing HormoneSex Hormone-Binding GlobulinSHBG protein, human

Identifiers

PMID38991999
PMCPMC11239811

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.