ArticleJournal of gynecologic oncology2025
Efficacy and safety of 3-dimensional printing noncoplanar template (3D-PNCT)-assisted high-dose-rate interstitial brachytherapy (HDR-ISBT) for reirradiation of recurrent cervical cancer: a prospective cohort.
Article in Journal of gynecologic oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Three-dimensional-printed template-assisted image-guided brachytherapy for cervical cancer: Technology, dosimetry, and clinical implementation.Journal of contemporary brachytherapy · 2026Review
- A Novel Three-Dimension Printed Individualized Curved-Needle-Based Interstitial Brachytherapy for Re-Irradiation in Uterine Fundus-Involving Recurrent Cervical Cancer: A Case Report.Current oncology (Toronto, Ont.) · 2026Article
- Article
- Worldwide research on 3D printing for cancer: a dual-method analysis of bibliometrics and stratified focused thematic.International journal of surgery (London, England) · 2026Review
- 3D-Printed Devices in Interventional Radiotherapy (Brachytherapy) Applications: A Literature Review.Journal of personalized medicine · 2025Review
- Article
- Freiburg flap used as vaginal applicator with/without free-hand interstitial needles in three-dimensional high-dose-rate brachytherapy for vaginal stump recurrence of cervical cancer.Journal of contemporary brachytherapy · 2024Article
- Development and Assessment of Interstitial Brachytherapy Using Individual Curved-Needle in Treatment of Recurrent Gynecological Tumors After External Beam Radiotherapy.Technology in cancer research & treatmentObservational
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to investigate the efficacy and safety of 3-dimensional printing noncoplanar template (3D-PNCT)-assisted computed tomography (CT)-guided high-dose-rate interstitial brachytherapy (HDR-ISBT) for reirradiation of pelvic recurrent cervical carcinoma after external beam radiotherapy.
methodsFrom January 2019 to August 2023, 45 eligible patients were enrolled in this prospective cohort. All patients underwent 3D-PNCT-assisted CT-guided HDR-ISBT with a prescribed dose of 4-7 Gy/fraction to the high-risk clinical target volume (HR-CTV) over 3-8 fractions, either for curative or palliative purposes. The primary endpoints were local progression-free survival (LPFS) and tumor response rate (TRR). The secondary outcome measures included overall survival (OS), toxicities, and symptom resolution.
resultsForty-five patients received 261 fractions of 3D-PNCT-assisted HDR-ISBT. Twenty-nine patients had isolated pelvic recurrence, and 16 patients had simultaneous extra-pelvic or distant recurrences. The TRR was 66.7%. The 2- and 5-year LPFS rates were 30.0% and 25.7%, respectively. The median OS was 23.2 months, and 2- and 5-year OS rates were 49.5% and 34.0%, respectively. The multivariate analysis indicated that squamous cell carcinoma, radical surgery, recurrence-free interval≥12 months, tumor diameter, pelvic recurrence type, and HR-CTV D₉₀≥45 Gy were independent factors influencing LPFS (all p<0.05). D₁₀₀≥21 Gy, V₁₀₀≥83%, and V₁₅₀≥45% were associated with better LPFS (all p<0.05). Tumor diameter and metastasis were independent predictive factors for OS (all p<0.05). The pain relief rate was 66.7% (10/15). Grade 3-4 toxicities occurred in 20.0% of patients.
conclusion3D-PNCT-assisted HDR-ISBT for reirradiation of recurrent cervical cancer proved to be an effective and safe alternative to radical surgery.
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