Evidence map›Paper›PMID 38991771›Full record

ArticleAJNR. American journal of neuroradiology2024

MR Cranial Bone Imaging: Evaluation of Both Motion-Corrected and Automated Deep Learning Pseudo-CT Estimated MR Images.

Andrew D Linkugel, Tongyao Wang, Parna Eshraghi Boroojeni, Cihat Eldeniz, Yasheng Chen, Gary B Skolnick, Paul K Commean, Corinne M Merrill, Jennifer M Strahle, Manu S Goyal and 2 more

Abstract read
In one paragraph

Article in AJNR. American journal of neuroradiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andrew D LinkugelFrom the Division of Plastic and Reconstructive Surgery (A.D.L., G.B.S., C.M.M., K.B.P.), Washington University in St. Louis, St. Louis, Missouri.ORCID 0000-0002-7601-2740
Tongyao WangMallinckrodt Institute of Radiology (T.W., P.E.B., C.E., P.K.C., M.S.G., H.A.), Washington University in St. Louis, St. Louis, Missouri.
Parna Eshraghi BoroojeniMallinckrodt Institute of Radiology (T.W., P.E.B., C.E., P.K.C., M.S.G., H.A.), Washington University in St. Louis, St. Louis, Missouri.
Cihat EldenizMallinckrodt Institute of Radiology (T.W., P.E.B., C.E., P.K.C., M.S.G., H.A.), Washington University in St. Louis, St. Louis, Missouri.ORCID 0000-0002-4457-0916
Yasheng ChenDepartment of Neurology (Y.C., H.A.), Washington University in St. Louis, St. Louis, Missouri.
Gary B SkolnickFrom the Division of Plastic and Reconstructive Surgery (A.D.L., G.B.S., C.M.M., K.B.P.), Washington University in St. Louis, St. Louis, Missouri.ORCID 0000-0003-1138-5201
Paul K CommeanMallinckrodt Institute of Radiology (T.W., P.E.B., C.E., P.K.C., M.S.G., H.A.), Washington University in St. Louis, St. Louis, Missouri.
Corinne M MerrillFrom the Division of Plastic and Reconstructive Surgery (A.D.L., G.B.S., C.M.M., K.B.P.), Washington University in St. Louis, St. Louis, Missouri.ORCID 0000-0002-4743-4143
Jennifer M StrahleDepartment of Neurosurgery (J.M.S.), Washington University in St. Louis, St. Louis, Missouri.
Manu S GoyalMallinckrodt Institute of Radiology (T.W., P.E.B., C.E., P.K.C., M.S.G., H.A.), Washington University in St. Louis, St. Louis, Missouri.ORCID 0000-0003-1970-4270
Hongyu AnMallinckrodt Institute of Radiology (T.W., P.E.B., C.E., P.K.C., M.S.G., H.A.), Washington University in St. Louis, St. Louis, Missouri.
Kamlesh B PatelFrom the Division of Plastic and Reconstructive Surgery (A.D.L., G.B.S., C.M.M., K.B.P.), Washington University in St. Louis, St. Louis, Missouri kamlesh.patel@wustl.edu.

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Robust and Rapid 3D High-Resolution Cranial bone imaging for pediatric patients using MRIR01EB032713 · NIBIB · WASHINGTON UNIVERSITY · PI AN, HONGYU, PATEL, KAMLESH · 2022 to 2025
$2.5M
NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NIBIB NIH HHS R01 EB032713
6 · The paper itself

Abstract

background and purposeCT imaging exposes patients to ionizing radiation. MR imaging is radiation free but previously has not been able to produce diagnostic-quality images of bone on a timeline suitable for clinical use. We developed automated motion correction and use deep learning to generate pseudo-CT images from MR images. We aim to evaluate whether motion-corrected pseudo-CT produces cranial images that have potential to be acceptable for clinical use. MATERIALS AND

methodsPatients younger than age 18 who underwent CT imaging of the head for either trauma or evaluation of cranial suture patency were recruited. Subjects underwent a 5-minute golden-angle stack-of-stars radial volumetric interpolated breath-hold MR image. Motion correction was applied to the MR imaging followed by a deep learning-based method to generate pseudo-CT images. CT and pseudo-CT images were evaluated and, based on indication for imaging, either presence of skull fracture or cranial suture patency was first recorded while viewing the MR imaging-based pseudo-CT and then recorded while viewing the clinical CT.

resultsA total of 12 patients underwent CT and MR imaging to evaluate suture patency, and 60 patients underwent CT and MR imaging for evaluation of head trauma. For cranial suture patency, pseudo-CT had 100% specificity and 100% sensitivity for the identification of suture closure. For identification of skull fractures, pseudo-CT had 100% specificity and 90% sensitivity.

conclusionsOur early results show that automated motion-corrected and deep learning-generated pseudo-CT images of the pediatric skull have potential for clinical use and offer a high level of diagnostic accuracy when compared with standard CT scans.

Indexed as

Deep LearningMagnetic Resonance ImagingTomography, X-Ray ComputedAdolescentChildChild, PreschoolCranial SuturesFemaleHumansMaleMotionSensitivity and SpecificitySkullSkull Fractures

Identifiers

PMID38991771
PMCPMC11392357

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.