Evidence map›Paper›PMID 38991769›Full record

ArticleAJNR. American journal of neuroradiology2024

Arterial Spin-Labeling MR Imaging in the Detection of Intracranial Arteriovenous Malformations in Patients with Hereditary Hemorrhagic Telangiectasia.

Adam Alyafaie, Woody Han, Yi Li, Samuel A Vydro, Maya Vella, Torianna L Truong, Lindsay Park, Daniel Langston, Helen Kim, Miles B Conrad and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Hereditary haemorrhagic telangiectasia.Nature reviews. Disease primers · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Adam AlyafaieFrom the School of Medicine (A.A., S.A.V.), University of California, San Francisco, San Francisco, California.ORCID 0000-0002-9773-8399
Woody HanDepartment of Radiology and Biomedical Imaging (W.H., Y.L., M.V.), University of California, San Francisco, San Francisco, California.
Yi LiDepartment of Radiology and Biomedical Imaging (W.H., Y.L., M.V.), University of California, San Francisco, San Francisco, California.ORCID 0000-0001-8535-2168
Samuel A VydroFrom the School of Medicine (A.A., S.A.V.), University of California, San Francisco, San Francisco, California.ORCID 0009-0006-9315-9257
Maya VellaDepartment of Radiology and Biomedical Imaging (W.H., Y.L., M.V.), University of California, San Francisco, San Francisco, California.ORCID 0000-0002-4816-5563
Torianna L TruongHHT Center of Excellence, Department of Radiology and Biomedical Imaging (T.L.T., L.P., D.L., M.B.C.), University of California, San Francisco, San Francisco, California.
Lindsay ParkHHT Center of Excellence, Department of Radiology and Biomedical Imaging (T.L.T., L.P., D.L., M.B.C.), University of California, San Francisco, San Francisco, California.
Daniel LangstonHHT Center of Excellence, Department of Radiology and Biomedical Imaging (T.L.T., L.P., D.L., M.B.C.), University of California, San Francisco, San Francisco, California.ORCID 0000-0003-2270-5477
Helen KimDepartment of Anesthesia, and Perioperative Care (H.K.), University of California, San Francisco, San Francisco, California.ORCID 0000-0002-1937-354X
Miles B ConradHHT Center of Excellence, Department of Radiology and Biomedical Imaging (T.L.T., L.P., D.L., M.B.C.), University of California, San Francisco, San Francisco, California.ORCID 0000-0002-7583-0493
Steven W HettsHHT Center of Excellence, Departments of Radiology, Biomedical Imaging, and Neurological Surgery (S.W.H.), University of California, San Francisco, San Francisco, California steven.hetts@ucsf.edu.ORCID 0000-0001-5885-7259

Funding

Endovascular Magnetic Catheter for Interventional MRIR01EB012031 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HETTS, STEVEN WILLIAM, MARTIN, ALASTAIR J · 2011 to 2021
$4.8M
NIBIB NIH HHS R01 EB012031
6 · The paper itself

Abstract

background and purposeHereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease that causes vascular malformations in a variety of organs and tissues, including brain AVMs. Because brain AVMs have the potential to cause disabling or fatal intracranial hemorrhage, detection of these lesions before rupture is the goal of screening MR imaging/MRA examinations in patients with HHT. Prior studies have demonstrated superior sensitivity for HHT-related brain AVMs by using postcontrast MR imaging sequences as compared with MRA alone. We now present data regarding the incremental benefit of including arterial spin-labeling (ASL) perfusion sequences as part of MR imaging/MRA screening in patients with this condition. MATERIALS AND

methodsWe retrospectively analyzed 831 patients at the UCSF Hereditary Hemorrhagic Telangiectasia Center of Excellence. Of these, 42 patients had complete MR imaging/MRA, ASL perfusion scans, and criterion-standard DSA data. Two neuroradiologists reviewed imaging studies and a third provided adjudication when needed.

resultsEight patients had no brain AVMs detected on DSA. The remaining 34 patients had 57 brain AVMs on DSA. Of the 57 identified AVMs, 51 (89.5%) were detected on ASL and 43 (75.4%) were detected on conventional MR imaging/MRA sequences (

conclusionsASL provides increased sensitivity for brain AVMs in patients with HHT. Inclusion of ASL should be considered as part of comprehensive MR imaging/MRA screening protocols for institutions taking care of patients with HHT.

Indexed as

Intracranial Arteriovenous MalformationsMagnetic Resonance AngiographySpin LabelsTelangiectasia, Hereditary HemorrhagicAdolescentAdultAgedFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesSensitivity and SpecificityYoung AdultSpin Labels

Identifiers

PMID38991769
PMCPMC11383423

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.