Evidence map›Paper›PMID 38991497›Full record

ArticleCell host & microbe2024

Combatting superbugs using the evolutionary record of microbial warfare.

Arjun S Raman

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell host & microbe, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Arjun S RamanDepartment of Pathology, University of Chicago, Chicago, IL, USA; Center for the Physics of Evolving Systems, University of Chicago, Chicago, IL, USA; Duchossois Family Institute, University of Chicago, Chicago, IL, USA. Electronic address: araman@bsd.uchicago.edu.

Funding

Using co-evolution to understand the emergence of bacterial phenotype from proteome variationR35GM146702 · NIGMS · UNIVERSITY OF CHICAGO · PI Arjun Raman · 2022 to 2026
$2.0M
NIGMS NIH HHS R35 GM146702
6 · The paper itself

Abstract

New therapies to treat multi-drug-resistant (MDR) pathogens are needed. Santos-Júnior et al. discover new antimicrobials by leveraging the history of warfare within microbial communities. This study in Cell highlights the immense power of combining large biological databases with emerging computational methods, creating a key resource (AMPSphere) to be used for treating superbugs.

Indexed as

Anti-Bacterial AgentsBacteriaComputational BiologyDrug Resistance, Multiple, BacterialHumansAnti-Bacterial Agents

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.