Evidence map›Paper›PMID 38991171›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2024

Neurofilament Light Chain Serum Levels Mirror Age and Disability in Secondary Progressive Multiple Sclerosis: A Cross-Sectional Study.

Leila Husseini, Jakob Jung, Natalie Boess, Niels Kruse, Stefan Nessler, Christine Stadelmann, Imke Metz, Michael Haupts, Martin S Weber

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PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Exercise Training and Biomarkers of Neuroaxonal Injury in Multiple Sclerosis: Narrative Review.International journal of environmental research and public health · 2026
    Review
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Leila HusseiniFrom the Department of Neurology (L.H., J.J., M.S.W.), University Medical Center Göttingen; Augustahospital Anholt (N.B.), Clinic of Neurology, Isselburg-Anholt; Department of Neuropathology (N.K., S.N., C.S., I.M., M.S.W.), University Medical Center Göttingen; Department of Neurology (M.H.), Heinrich Heine University, Düsseldorf; and Fraunhofer Institute for Translational Medicine and Pharmacology ITMP (M.S.W.), Göttingen, Germany.
Jakob JungFrom the Department of Neurology (L.H., J.J., M.S.W.), University Medical Center Göttingen; Augustahospital Anholt (N.B.), Clinic of Neurology, Isselburg-Anholt; Department of Neuropathology (N.K., S.N., C.S., I.M., M.S.W.), University Medical Center Göttingen; Department of Neurology (M.H.), Heinrich Heine University, Düsseldorf; and Fraunhofer Institute for Translational Medicine and Pharmacology ITMP (M.S.W.), Göttingen, Germany.ORCID 0009-0003-2943-1314
Natalie BoessFrom the Department of Neurology (L.H., J.J., M.S.W.), University Medical Center Göttingen; Augustahospital Anholt (N.B.), Clinic of Neurology, Isselburg-Anholt; Department of Neuropathology (N.K., S.N., C.S., I.M., M.S.W.), University Medical Center Göttingen; Department of Neurology (M.H.), Heinrich Heine University, Düsseldorf; and Fraunhofer Institute for Translational Medicine and Pharmacology ITMP (M.S.W.), Göttingen, Germany.ORCID 0009-0007-6918-0934
Niels KruseFrom the Department of Neurology (L.H., J.J., M.S.W.), University Medical Center Göttingen; Augustahospital Anholt (N.B.), Clinic of Neurology, Isselburg-Anholt; Department of Neuropathology (N.K., S.N., C.S., I.M., M.S.W.), University Medical Center Göttingen; Department of Neurology (M.H.), Heinrich Heine University, Düsseldorf; and Fraunhofer Institute for Translational Medicine and Pharmacology ITMP (M.S.W.), Göttingen, Germany.
Stefan NesslerFrom the Department of Neurology (L.H., J.J., M.S.W.), University Medical Center Göttingen; Augustahospital Anholt (N.B.), Clinic of Neurology, Isselburg-Anholt; Department of Neuropathology (N.K., S.N., C.S., I.M., M.S.W.), University Medical Center Göttingen; Department of Neurology (M.H.), Heinrich Heine University, Düsseldorf; and Fraunhofer Institute for Translational Medicine and Pharmacology ITMP (M.S.W.), Göttingen, Germany.
Christine StadelmannFrom the Department of Neurology (L.H., J.J., M.S.W.), University Medical Center Göttingen; Augustahospital Anholt (N.B.), Clinic of Neurology, Isselburg-Anholt; Department of Neuropathology (N.K., S.N., C.S., I.M., M.S.W.), University Medical Center Göttingen; Department of Neurology (M.H.), Heinrich Heine University, Düsseldorf; and Fraunhofer Institute for Translational Medicine and Pharmacology ITMP (M.S.W.), Göttingen, Germany.ORCID 0000-0003-1766-5458
Imke MetzFrom the Department of Neurology (L.H., J.J., M.S.W.), University Medical Center Göttingen; Augustahospital Anholt (N.B.), Clinic of Neurology, Isselburg-Anholt; Department of Neuropathology (N.K., S.N., C.S., I.M., M.S.W.), University Medical Center Göttingen; Department of Neurology (M.H.), Heinrich Heine University, Düsseldorf; and Fraunhofer Institute for Translational Medicine and Pharmacology ITMP (M.S.W.), Göttingen, Germany.ORCID 0000-0002-6571-7630
Michael HauptsFrom the Department of Neurology (L.H., J.J., M.S.W.), University Medical Center Göttingen; Augustahospital Anholt (N.B.), Clinic of Neurology, Isselburg-Anholt; Department of Neuropathology (N.K., S.N., C.S., I.M., M.S.W.), University Medical Center Göttingen; Department of Neurology (M.H.), Heinrich Heine University, Düsseldorf; and Fraunhofer Institute for Translational Medicine and Pharmacology ITMP (M.S.W.), Göttingen, Germany.
Martin S WeberFrom the Department of Neurology (L.H., J.J., M.S.W.), University Medical Center Göttingen; Augustahospital Anholt (N.B.), Clinic of Neurology, Isselburg-Anholt; Department of Neuropathology (N.K., S.N., C.S., I.M., M.S.W.), University Medical Center Göttingen; Department of Neurology (M.H.), Heinrich Heine University, Düsseldorf; and Fraunhofer Institute for Translational Medicine and Pharmacology ITMP (M.S.W.), Göttingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo assess neurofilament light chain serum (sNfL) levels in patients with secondary progressive multiple sclerosis (SP-MS).

methodsUsing a single molecule array, we analyzed sNfL levels in a cross-sectional cohort study of 153 patients with SP-MS hospitalized for rehabilitation in a clinic specialized in the care for patients with multiple sclerosis (MS). In addition, we investigated the correlation of disease activity with sNfL levels in 36 patients with relapsing-remitting MS (RR-MS).

resultsMean sNfL levels in patients with SP-MS were consistently elevated when compared with age-matched controls and patients with RR-MS. In SP-MS, age dependency of sNfL levels was pronounced, whereas patients with RR-MS younger than 41 years without recent disease activity were not distinguishable from age-matched healthy controls. In a multivariate analysis, clinical disability was a risk factor for elevated sNfL levels in SP-MS, whereas no correlation with comorbidities, such as cardiovascular disease, diabetes mellitus, smoking status, or vitamin D serum levels, could be detected. DISCUSSION: These findings highlight that measurement of sNfL levels represents a useful tool to assess the extent of neuroaxonal damage as a surrogate for clinical progression in patients with SP-MS, when age and disease activity as major confounders are taken into account.

Indexed as

Multiple Sclerosis, Chronic ProgressiveMultiple Sclerosis, Relapsing-RemittingNeurofilament ProteinsAdultAgedAge FactorsBiomarkersCohort StudiesCross-Sectional StudiesDisability EvaluationFemaleHumansMaleMiddle AgedBiomarkersneurofilament protein LNeurofilament Proteins

Identifiers

PMID38991171
PMCPMC11256980

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.