Evidence map›Paper›PMID 38991122›Full record

ArticleEpigenetics2024

Transgenerational epigenetic self-memory of

M Elena Martinez, Aldona Karaczyn, Zhaofei Wu, Christian A Bennett, Kassey L Matoin, Heather M Daigle, Arturo Hernandez

Abstract read
In one paragraph

Article in Epigenetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Summary of the Year in Review Lectures at the 2024 Annual Meeting of the American Thyroid Association.Thyroid : official journal of the American Thyroid Association · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

M Elena MartinezCenter for Molecular Medicine, MaineHealth Institute for Research, MaineHealth, Scarborough, ME, USA.
Aldona KaraczynCenter for Molecular Medicine, MaineHealth Institute for Research, MaineHealth, Scarborough, ME, USA.
Zhaofei WuCenter for Molecular Medicine, MaineHealth Institute for Research, MaineHealth, Scarborough, ME, USA.
Christian A BennettCenter for Molecular Medicine, MaineHealth Institute for Research, MaineHealth, Scarborough, ME, USA.
Kassey L MatoinCenter for Molecular Medicine, MaineHealth Institute for Research, MaineHealth, Scarborough, ME, USA.
Heather M DaigleCenter for Molecular Medicine, MaineHealth Institute for Research, MaineHealth, Scarborough, ME, USA.
Arturo HernandezCenter for Molecular Medicine, MaineHealth Institute for Research, MaineHealth, Scarborough, ME, USA.ORCID 0000-0002-6314-3987

Funding

Understanding Factors Influencing COVID-19 Testing and Vaccination in Immigrant Low-income and Homeless Populations and Testing Targeted InterventionsU54GM115516 · NIGMS · MAINEHEALTH · PI Kimberly Luebbers · 2017 to 2026
$51.6M
The role of night shift work in metabolic disorders during and after pregnancyP20GM121301 · NIGMS · MAINEHEALTH · PI Lucy Liaw · 2017 to 2026
$25.1M
Progenitor Cell Analysis CoreP30GM106391 · NIGMS · MAINEHEALTH · PI WOJCHOWSKI, DON MICHAEL · 2013 to 2017
$5.7M
Transgenerational Epigenetic Programming of the Thyroid AxisR01DK095908 · NIDDK · MAINEHEALTH · PI Arturo Hernandez · 2012 to 2026
$5.1M
Epigenetic Influence on Thyroid Hormone Action in the Brain and on BehaviorR01MH096050 · NIMH · MAINEHEALTH · PI HERNANDEZ, ARTURO · 2012 to 2022
$3.9M
NIDDK NIH HHS R01 DK095908NIGMS NIH HHS P20 GM121301NIGMS NIH HHS P30 GM106391NIGMS NIH HHS U54 GM115516NIMH NIH HHS R01 MH096050
6 · The paper itself

Abstract

Intergenerational and transgenerational epigenetic effects resulting from conditions in previous generations can contribute to environmental adaptation as well as disease susceptibility. Previous studies in rodent and human models have shown that abnormal developmental exposure to thyroid hormone affects endocrine function and thyroid hormone sensitivity in later generations. Since the imprinted type 3 deiodinase gene (

Indexed as

DNA MethylationEpigenesis, GeneticIodide PeroxidaseThyroid HormonesAnimalsAnimals, NewbornFemaleGenomic ImprintingMaleMiceMice, KnockoutPregnancyRNA, Long NoncodingIodide Peroxidaseiodothyronine deiodinase type IIIMEG3 non-coding RNA, mouseRNA, Long NoncodingThyroid Hormonesdevelopmental growthDio3Dlk1-Dio3 imprinted domainDNA methylationMeg3neonatal leptinThyroid hormonetransgenerational epigenetics

Identifiers

PMID38991122
PMCPMC11244338

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.