Evidence map›Paper›PMID 38991008›Full record

ArticleAmerican journal of physiology. Renal physiology2024

An efficient inducible model for the control of gene expression in renin cells.

Silvia Medrano, Manako Yamaguchi, Lucas Ferreira de Almeida, Jason P Smith, Hiroki Yamaguchi, Curt D Sigmund, Maria Luisa S Sequeira-Lopez, R Ariel Gomez

Abstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Silvia MedranoDepartment of Pediatrics, Child Health Research Center, University of Virginia, Charlottesville, Virginia, United States.ORCID 0000-0002-8516-0788
Manako YamaguchiDepartment of Pediatrics, Child Health Research Center, University of Virginia, Charlottesville, Virginia, United States.ORCID 0000-0002-2880-9165
Lucas Ferreira de AlmeidaDepartment of Pediatrics, Child Health Research Center, University of Virginia, Charlottesville, Virginia, United States.
Jason P SmithDepartment of Pediatrics, Child Health Research Center, University of Virginia, Charlottesville, Virginia, United States.ORCID 0000-0002-2688-0988
Hiroki YamaguchiDepartment of Pediatrics, Child Health Research Center, University of Virginia, Charlottesville, Virginia, United States.
Curt D SigmundDepartment of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.ORCID 0000-0002-1453-0921
Maria Luisa S Sequeira-LopezDepartment of Pediatrics, Child Health Research Center, University of Virginia, Charlottesville, Virginia, United States.
R Ariel GomezDepartment of Pediatrics, Child Health Research Center, University of Virginia, Charlottesville, Virginia, United States.ORCID 0000-0002-5124-8255

Funding

Role of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI SIGMUND, CURT DANIEL · 2007 to 2022
$30.2M
Single-Cell Epigenomics, Transcriptomics, and Bioinformatics CoreP50DK096373 · NIDDK · UNIVERSITY OF VIRGINIA · PI ROBERTO Ariel GOMEZ · 2012 to 2026
$13.8M
PPARG-dependent Mechanisms Control Endothelial-Smooth Muscle Coordination, Arterial Pressure, Vasomotor Function and Arterial StiffnessR35HL144807 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI SIGMUND, CURT DANIEL · 2019 to 2024
$5.5M
Plasticity of renin cells in the kidney vasculatureR01DK116718 · NIDDK · UNIVERSITY OF VIRGINIA · PI GOMEZ, ROBERTO ARIEL · 2018 to 2022
$2.8M
Renin cell identity and blood pressure homeostasisR01HL148044 · NHLBI · UNIVERSITY OF VIRGINIA · PI SEQUEIRA-LOPEZ, MARIA LUISA SOLEDAD · 2020 to 2023
$2.7M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL148044HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) P50 DK-096373HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) R01 DK-116718NHLBI NIH HHS P01 HL084207NHLBI NIH HHS R01 HL148044NHLBI NIH HHS R35 HL144807NIDDK NIH HHS P50 DK096373NIDDK NIH HHS R01 DK116718
6 · The paper itself

Abstract

Fate mapping and genetic manipulation of renin cells have relied on either noninducible

Indexed as

Mice, TransgenicReninAldehyde ReductaseAnimalsCaptoprilGene Expression RegulationGreen Fluorescent ProteinsIntegrasesJuxtaglomerular ApparatusMiceAldehyde ReductaseCaptoprilCre recombinaseGreen Fluorescent ProteinsIntegrasesReninarteriolar hypertrophygene targetinglineage tracingrenin cellsrenin deletion

Identifiers

PMID38991008
PMCPMC11460331

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.