Evidence map›Paper›PMID 38990891›Full record

ArticleClinical and experimental immunology2025

T cells immune imbalance presents in patients with multiple intracranial aneurysms.

Chuming Tao, Chenglong Liu, Peicong Ge, Liujia Chan, Yuheng Pang, Junsheng Li, Qiheng He, Wei Liu, Siqi Mou, Zhiyao Zheng and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Chuming TaoDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Chenglong LiuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-8449-6343
Peicong GeDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Liujia ChanBeijing Institute of Hepatology, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Yuheng PangBeijing Institute of Hepatology, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Junsheng LiDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Qiheng HeDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Wei LiuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Siqi MouDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Zhiyao ZhengDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Bojian ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Zhikang ZhaoDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Wei SunDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Qian ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Rong WangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yan ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Wenjing WangBeijing Institute of Hepatology, Beijing YouAn Hospital, Capital Medical University, Beijing, China.
Dong ZhangDepartment of Neurosurgery, Beijing Hospital, National Center of Gerontology, Beijing, China.
Jizong ZhaoDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Funding

National Key Research and Development Program of China 2021YFC2500502National Natural Science Foundation of China 82301451
6 · The paper itself

Abstract

Growing evidence suggests that systemic immune and inflammatory responses may play a critical role in the formation and development of aneurysms. Exploring the differences between single intracranial aneurysm (SIA) and multiple IAs (MIAs) could provide insights for targeted therapies. However, there is a lack of comprehensive and detailed characterization of changes in circulating immune cells in MIAs. Peripheral blood mononuclear cell (PBMC) samples from patients with SIA (n = 16) or MIAs (n = 6) were analyzed using high-dimensional mass cytometry to evaluate the frequency and phenotype of immune cell subtypes. A total of 25 cell clusters were identified, revealing that the immune signature of MIAs included cluster changes. Compared to patients with SIA, patients with MIAs exhibited immune dysfunction and regulatory imbalance in T-cell clusters. They also had reduced numbers of CD8+ T cells and their subgroups CD8+ Te and CD8+ Tem cells, as well as reduced numbers of the CD4+ T-cell subgroup CD27-CD4+ Tem cells. Furthermore, compared to SIA, MIAs were associated with enhanced T-cell immune activation, with elevated expression levels of CD3, CD25, CD27, CCR7, GP130, and interleukin 10. This study provides insights into the circulating immune cell profiles in patients with MIAs, highlighting the similarities and differences between patients with SIA and those with MIAs. Furthermore, the study suggests that circulating immune dysfunction may contribute to the development of MIAs.

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesIntracranial AneurysmT-LymphocytesT-Lymphocyte SubsetsAdultAgedFemaleHumansImmunophenotypingLeukocytes, MononuclearLymphocyte ActivationMaleMiddle Agedcirculating immune celllandscapemass cytometrymultiple intracranial aneurysms

Identifiers

PMID38990891
PMCPMC11771201

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