Evidence map›Paper›PMID 38990450›Full record

ArticleCurrent medical science2024

Electroacupuncture Alleviates Memory Deficits in APP/PS1 Mice by Targeting Serotonergic Neurons in Dorsal Raphe Nucleus.

Chao-Chao Yu, Xiao-Fei Wang, Jia Wang, Chu Li, Juan Xiao, Xue-Song Wang, Rui Han, Shu-Qin Wang, Yuan-Fang Lin, Li-Hong Kong and 1 more

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Article in Current medical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
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  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Chao-Chao Yu *Department of Rehabilitation, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Xiao-Fei Wang *Department of Rehabilitation, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, 430074, China.
Jia WangDepartment of Acupuncture and Moxibustion, Wuhan Hospital of Integrated Traditional Chinese and Western Medicine, Wuhan, 430030, China.
Chu LiDepartment of Tuina, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, 518000, China.
Juan XiaoCollege of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, 430065, China.
Xue-Song WangCollege of Acupuncture-Moxibustion and Tuina, Hebei University of Chinese Medicine, Shijiazhuang, 050299, China.
Rui HanDepartment of Child Rehabilitation Medicine, Qujing Hospital of Maternity and Childcare, Qujing, 655002, China.
Shu-Qin WangDepartment of Tuina, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, 518000, China.
Yuan-Fang LinDepartment of Tuina, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, 518000, China.
Li-Hong KongCollege of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, 430065, China. xiyu1618@sina.com.
Yan-Jun DuCollege of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, 430065, China. yjdu-acu@hbtcm.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAlzheimer's disease (AD) has become a significant global concern, but effective drugs able to slow down AD progression is still lacked. Electroacupuncture (EA) has been demonstrated to ameliorate cognitive impairment in individuals with AD. However, the underlying mechanisms remains poorly understood. This study aimed at examining the neuroprotective properties of EA and its potential mechanism of action against AD.

methodsAPP/PS1 transgenic mice were employed to evaluate the protective effects of EA on Shenshu (BL 23) and Baihui (GV 20). Chemogenetic manipulation was used to activate or inhibit serotonergic neurons within the dorsal raphe nucleus (DRN). Learning and memory abilities were assessed by the novel object recognition and Morris water maze tests. Golgi staining, western blot, and immunostaining were utilized to determine EA-induced neuroprotection.

resultsEA at Shenshu (BL 23) and Baihui (GV 20) effectively ameliorated learning and memory impairments in APP/PS1 mice. EA attenuated dendritic spine loss, increased the expression levels of PSD95, synaptophysin, and brain-derived neurotrophic factor in hippocampus. Activation of serotonergic neurons within the DRN can ameliorate cognitive deficits in AD by activating glutamatergic neurons mediated by 5-HT

conclusionEA can alleviate cognitive dysfunction in APP/PS1 mice by activating serotonergic neurons in the DRN. Further study is necessary to better understand how the serotonergic neurons-related neural circuits involves in EA-induced memory improvement in AD.

Indexed as

Alzheimer DiseaseDisease Models, AnimalDorsal Raphe NucleusElectroacupunctureMemory DisordersSerotonergic NeuronsAmyloid beta-Protein PrecursorAnimalsBrain-Derived Neurotrophic FactorHippocampusHumansMaleMaze LearningMiceMice, TransgenicPresenilin-1Amyloid beta-Protein PrecursorBrain-Derived Neurotrophic FactorPresenilin-1Synaptophysin5-HT1BAlzheimer’s diseasechemogenetic manipulationcognitive impairmentdorsal raphe nucleuselectroacupunctureglutamatergic neuronshippocampusserotonergic neuronssynaptic plasticity

Identifiers

PMID38990450

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.