Evidence map›Paper›PMID 38990427›Full record

ArticleEuropean journal of drug metabolism and pharmacokinetics2024

In Vitro Ciclopirox Glucuronidation in Liver Microsomes from Humans and Various Experimental Animals.

Wenjing Li, Yufan Xue, Feng Zhang, Ling Xiao, Zhu Huang, Wenjuan Li, Liangliang Zhu, Guangbo Ge

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In one paragraph

Article in European journal of drug metabolism and pharmacokinetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenjing LiSchool of Life Science, Innovation Center of Targeted Development of Medicinal Resources (iCTM), Anqing Normal University, 1318 Jixianbei Road, Anqing, 246133, People's Republic of China.
Yufan XueSchool of Life Science, Innovation Center of Targeted Development of Medicinal Resources (iCTM), Anqing Normal University, 1318 Jixianbei Road, Anqing, 246133, People's Republic of China.
Feng ZhangShanghai Frontiers Science Center of TCM Chemical Biology and Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, People's Republic of China.
Ling XiaoSchool of Resources and Environment, Anqing Normal University, Anqing, 246311, People's Republic of China.
Zhu HuangSchool of Life Science, Innovation Center of Targeted Development of Medicinal Resources (iCTM), Anqing Normal University, 1318 Jixianbei Road, Anqing, 246133, People's Republic of China.
Wenjuan LiSchool of Life Science, Innovation Center of Targeted Development of Medicinal Resources (iCTM), Anqing Normal University, 1318 Jixianbei Road, Anqing, 246133, People's Republic of China.
Liangliang ZhuSchool of Life Science, Innovation Center of Targeted Development of Medicinal Resources (iCTM), Anqing Normal University, 1318 Jixianbei Road, Anqing, 246133, People's Republic of China. zhuliangliang@aqnu.edu.cn.ORCID http://orcid.org/0000-0002-3865-9092
Guangbo GeShanghai Frontiers Science Center of TCM Chemical Biology and Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, 201203, People's Republic of China. geguangbo@shutcm.edu.cn.

Funding

Natural Science Research Project of Anhui Educational Committee 2023AH050507Opening Foundation of Provincial Key Laboratory of Biodiversity Study and Ecology Conservation Wsz202208
6 · The paper itself

Abstract

BACKGROUND AND

objectiveCiclopirox is a widely used antifungal drug, redisposition of which has drawn increasing attentions due to multiple promising activities. The drug undergoes extensive glucuronidation, which acts as a major obstacle in the ongoing novel application and still remains poorly understood. The current study aims to phenotype ciclopirox glucuronidation pathway and as well to decipher the related species differences.

methodsCiclopirox glucuronidation was investigated in liver microsomes from humans (HLM) and various experimental animals. Assays with recombinant uridine diphosphate glucuronosyltransferases (UGTs), enzyme kinetic analyses and selective inhibitors were used to determine the role of individual UGTs in ciclopirox glucuronidation.

resultsHLM is highly active in ciclopirox glucuronidation with Michaelis-Menten constant (K

conclusionsCiclopirox glucuronidation displays remarkable species differences with UGT1A9 as a dominant contributor in humans. It is suggested that the pharmacological or toxicological effects of ciclopirox may be UGT1A9 and species dependent.

Indexed as

Antifungal AgentsCiclopiroxGlucuronidesGlucuronosyltransferaseMicrosomes, LiverAnimalsDogsHumansKineticsMacaca fascicularisMaleMiceRatsRats, Sprague-DawleySpecies SpecificitySwineAntifungal AgentsCiclopiroxGlucuronidesGlucuronosyltransferase

Identifiers

PMID38990427

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.