Evidence map›Paper›PMID 38990362›Full record

ArticleVirchows Archiv : an international journal of pathology2024

Pediatric thyroid-like follicular renal cell carcinoma-a post-neuroblastoma case with comprehensive genomic profiling data.

Richárd Kiss, Tamás Micsik, Gábor Bedics, Gergő Papp, Monika Csóka, Zoltán Jenővári, Sándor Szabó, Tamás Tornóczki, Gordan Vujanic, Levente Kuthi

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Richárd Kiss *Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Tamás Micsik *Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Gábor BedicsDepartment of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Gergő PappDepartment of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary.
Monika CsókaTűzoltó Street Department, Pediatric Center, Semmelweis University, Budapest, Hungary.
Zoltán JenőváriTűzoltó Street Department, Pediatric Center, Semmelweis University, Budapest, Hungary.
Sándor SzabóTűzoltó Street Department, Pediatric Center, Semmelweis University, Budapest, Hungary.
Tamás TornóczkiDepartment of Pathology, Faculty of Medicine and Clinical Center, University of Pécs, Pécs, Hungary.
Gordan VujanicDepartment of Pathology, Sidra Medicine, Doha, Qatar.
Levente KuthiDepartment of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary. kuthilevente@gmail.com.ORCID http://orcid.org/0000-0001-9247-6679

Funding

Magyarország Kormánya ÚNKP-23-4-305Szent-Györgyi Albert Orvostudományi Kar, Szegedi Tudományegyetem 5S 340 A202
6 · The paper itself

Abstract

Thyroid-like follicular renal cell carcinoma (TLFRCC), an emerging subtype of renal cell carcinoma, presents diagnostic challenges due to its resemblance to normal thyroid tissue. Here, we report a rare case of TLFRCC in a pediatric patient, a demographic rarely affected by this subtype. Histologically resembling a typical TLFRCC, our case exhibited unique features including post-neuroblastoma development, occurrence in a male teenager, and diffuse MelanA expression, which has not been previously reported in TLFRCC. Comprehensive genomic profiling revealed the EWSR1::PATZ1 fusion, confirming its genetic basis. Due to the advanced tumor stage, the patient received combined immunotherapy, and after a 9-month follow-up, remains tumor-free. Our case broadens the diagnostic spectrum of pediatric renal cell carcinomas, highlighting the importance of comprehensive molecular profiling in rare subtypes such as TLFRCC. Further research is needed to better understand TLFRCC's genetic landscape and optimize therapeutic strategies, especially in pediatric populations with evolving treatment protocols.

Indexed as

Carcinoma, Renal CellKidney NeoplasmsNeuroblastomaAdolescentBiomarkers, TumorGene Expression ProfilingHumansMaleThyroid NeoplasmsBiomarkers, TumorComprehensive genomic profilingEWSR1::PATZ1Renal cell carcinomaThyroid-like follicular carcinoma

Identifiers

PMID38990362

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.