Evidence map›Paper›PMID 38990199›Full record

ArticleJournal of natural products2024

Discovery of Uncommon Tryptophan-Containing Diketopiperazines from

Cory B Jenkinson, Shu-Yi Lin, Mary Villarreal, C Elizabeth Oakley, David H Sherman, Ching-Kuo Lee, Clay C C Wang, Berl R Oakley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of natural products, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Genetic Dereplication of MultipleJournal of natural products · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cory B JenkinsonDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045, United States.
Shu-Yi LinSchool of Pharmacy, National Defense Medical Center, Taipei, 11490, Taiwan.ORCID 0000-0001-7982-136X
Mary VillarrealDepartment of Pharmacology and Pharmaceutical Sciences, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90089, United States.
C Elizabeth OakleyDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045, United States.ORCID 0000-0001-7170-4775
David H ShermanLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0001-8334-3647
Ching-Kuo LeeSchool of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.
Clay C C WangDepartment of Pharmacology and Pharmaceutical Sciences, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90089, United States.ORCID 0000-0003-2955-7569
Berl R OakleyDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045, United States.ORCID 0000-0002-3046-8240

Funding

Development of natural product inhibitors of Nef for clearance of HIV reservoirsR01AI148383 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L., SHERMAN, DAVID H · 2019 to 2023
$3.8M
Resistance-gene-guided genome mining for novel antifungal compoundsR21AI156320 · NIAID · UNIVERSITY OF KANSAS LAWRENCE · PI OAKLEY, BERL RAY · 2021 to 2022
$437k
NIAID NIH HHS R01 AI148383NIAID NIH HHS R21 AI156320
6 · The paper itself

Abstract

Fungal secondary metabolite (SM) biosynthetic gene clusters (BGCs) containing dimethylallyltryptophan synthases (DMATSs) produce structurally diverse prenylated indole alkaloids with wide-ranging activities that have vast potential as human therapeutics. To discover new natural products produced by DMATSs, we mined the Department of Energy Joint Genome Institute's MycoCosm database for DMATS-containing BGCs. We found a DMATS BGC in

Indexed as

AspergillusAspergillus nidulansDiketopiperazinesPeptide SynthasesTryptophanAlkyl and Aryl TransferasesIndole AlkaloidsMolecular StructureMultigene FamilyAlkyl and Aryl TransferasesDiketopiperazinesIndole Alkaloidsnon-ribosomal peptide synthasePeptide SynthasesTryptophan

Identifiers

PMID38990199
PMCPMC12502644

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.