Evidence map›Paper›PMID 38990111›Full record

ReviewCurrent opinion in organ transplantation2024

Progress towards permanent respiratory support.

Suji Shin, Umar Nasim, Hassana O'Connor, Yeahwa Hong

Abstract readReview
In one paragraph

Review in Current opinion in organ transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Suji ShinDepartment of Biomedical Engineering, Carnegie Mellon University.
Umar NasimDepartment of Biomedical Engineering, Carnegie Mellon University.
Hassana O'ConnorDepartment of Biomedical Engineering, Carnegie Mellon University.
Yeahwa HongDepartment of Biomedical Engineering, Carnegie Mellon University.

Funding

Cardiothoracic Surgery Research Training ProgramT32HL160526 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JAMES D LUKETICH, Julie A Phillippi · 2022 to 2026
$1.5M
NHLBI NIH HHS T32 HL160526
6 · The paper itself

Abstract

purpose of reviewAlthough lung transplantation stands as the gold standard curative therapy option for end-stage lung disease, the scarcity of available organs poses a significant challenge in meeting the escalating demand. This review provides an overview of recent advancements in ambulatory respiratory assist systems, selective anticoagulation therapies that target the intrinsic pathway, and innovative surface coatings to enable permanent respiratory support as a viable alternative to lung transplantation. RECENT

findingsSeveral emerging ambulatory respiratory assist systems have shown promise in both preclinical and clinical trials. These systems aim to create more biocompatible, compact, and portable forms of extracorporeal membrane oxygenation that can provide long-term respiratory support. Additionally, innovative selective anticoagulation strategies, currently in various stages of preclinical or clinical development, present a promising alternative to currently utilized nonselective anticoagulants. Moreover, novel surface coatings hold the potential to locally prevent artificial surface-induced thrombosis and minimize bleeding risks. SUMMARY: This review of recent advancements toward permanent respiratory support summarizes the development of ambulatory respiratory assist systems, selective anticoagulation therapies, and novel surface coatings. The integration of these evolving device technologies with targeted anticoagulation strategies may allow a safe and effective mode of permanent respiratory support for patients with chronic lung disease.

Indexed as

AnticoagulantsExtracorporeal Membrane OxygenationAnimalsBlood CoagulationCoated Materials, BiocompatibleEquipment DesignHumansLung DiseasesLung TransplantationThrombosisTreatment OutcomeAnticoagulantsCoated Materials, Biocompatible

Identifiers

PMID38990111
PMCPMC11488683

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.