Evidence map›Paper›PMID 38989990›Full record

ArticleFuture medicinal chemistry2024

Development of 5-hydroxybenzothiophene derivatives as multi-kinase inhibitors with potential anti-cancer activity.

Yara A Abd El-Rahman, Po-Jen Chen, Ahmed K ElHady, Shun-Hua Chen, Hsin-Chieh Lin, Dalia S El-Gamil, Youssef Aboushady, Ashraf H Abadi, Matthias Engel, Mohammad Abdel-Halim

Abstract read
In one paragraph

Article in Future medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yara A Abd El-RahmanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy & Biotechnology, German University in Cairo, Cairo, 11835, Egypt.ORCID 0009-0006-3423-5598
Po-Jen ChenDepartment of Medical Research, E-Da Hospital, I-Shou University, Kaohsiung, 824410, Taiwan.ORCID 0000-0002-0135-8798
Ahmed K ElHadyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy & Biotechnology, German University in Cairo, Cairo, 11835, Egypt.ORCID 0000-0002-5207-3004
Shun-Hua ChenSchool of Nursing, Fooyin University, Kaohsiung, 831301, Taiwan.ORCID 0000-0002-6158-5829
Hsin-Chieh LinDepartment of Chinese Medicine, E-Da Cancer Hospital, Kaohsiung, 824410, Taiwan.ORCID 0000-0002-5529-9746
Dalia S El-GamilDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy & Biotechnology, German University in Cairo, Cairo, 11835, Egypt.ORCID 0000-0002-0512-6724
Youssef AboushadyDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy & Biotechnology, German University in Cairo, Cairo, 11835, Egypt.ORCID 0009-0007-6700-8700
Ashraf H AbadiDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy & Biotechnology, German University in Cairo, Cairo, 11835, Egypt.ORCID 0000-0002-7433-261X
Matthias EngelPharmaceutical & Medicinal Chemistry, Saarland University, Campus C2.3, D-66123, Saarbrücken, Germany.ORCID 0000-0001-5065-8634
Mohammad Abdel-HalimDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy & Biotechnology, German University in Cairo, Cairo, 11835, Egypt.ORCID 0000-0003-1326-4219

Funding

E-Da Hospital EDAHJ112016, EDAHS112009, and NCKUEDA11205National Science and Technology Council 112-2320-B-650-001 and 112-2321-B-255-001
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antineoplastic AgentsApoptosisCell ProliferationDrug Screening Assays, AntitumorProtein Kinase InhibitorsThiophenesCell Line, TumorCell MovementHumansMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsProtein Kinase InhibitorsThiophenesanticancer agentsClk1/4DRAK1Dyrk1A/Bhaspinmulti-kinase inhibitors

Identifiers

PMID38989990
PMCPMC11249150

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.