Evidence map›Paper›PMID 38989989›Full record

ArticleFuture medicinal chemistry2024

Synthesis of 2,4-dihydroxyacetophenone derivatives as potent PDE-1 and -3 inhibitors:

Aftab Alam, Sana Gul, Zainab, Majid Khan, Ahmed A Elhenawy, Mohammad Shahidul Islam, Mumtaz Ali, Syed Adnan Ali Shah, Abdul Latif, Manzoor Ahmad

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aftab AlamDepartment of Chemistry, University of Malakand, P.O. Box 18800, Dir Lower, Pakistan.ORCID 0000-0003-0475-2376
Sana GulDepartment of Chemistry, University of Malakand, P.O. Box 18800, Dir Lower, Pakistan.
ZainabCollege of Chemistry & Materials Science, Hebei Normal University, Shijiazhuang, 050024, China.
Majid KhanH.E.J. Research Institute of Chemistry, International Center for Chemical & Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Ahmed A ElhenawyChemistry Department, Faculty of Science, Al-Azhar University, Nasr City, 11884, Cairo, Egypt.
Mohammad Shahidul IslamDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Mumtaz AliDepartment of Chemistry, University of Malakand, P.O. Box 18800, Dir Lower, Pakistan.
Syed Adnan Ali ShahFaculty of Pharmacy, Universiti Teknologi MARA Puncak Alam Campus, 42300 Bandar Puncak Alam,Selangor D. E., Malaysia.
Abdul LatifDepartment of Chemistry, University of Malakand, P.O. Box 18800, Dir Lower, Pakistan.
Manzoor AhmadDepartment of Chemistry, University of Malakand, P.O. Box 18800, Dir Lower, Pakistan.ORCID 0000-0001-9736-5900

Funding

Higher Education Research Endowment HED-041King Saud University RSPD2024R1100
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AcetophenonesCyclic Nucleotide Phosphodiesterases, Type 1Molecular Docking SimulationPhosphodiesterase InhibitorsCatalytic DomainHumansMolecular StructureSchiff BasesStructure-Activity RelationshipAcetophenonesCyclic Nucleotide Phosphodiesterases, Type 1Phosphodiesterase InhibitorsSchiff Bases2,4-dihydroxyacetophenonebis-Schiff basesmolecular dockingphosphodiesterase 1 and 3spectroscopystructure–activity relationship

Identifiers

PMID38989989
PMCPMC11382721

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.