Evidence map›Paper›PMID 38989466›Full record

ArticleiScience2024

Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication.

Shengli Ming, Shijun Zhang, Jiayou Xing, Guoyu Yang, Lei Zeng, Jiang Wang, Beibei Chu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Retinoic acid in health and disease.Signal transduction and targeted therapy · 2026
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shengli MingCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, Henan Province, China.
Shijun ZhangCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, Henan Province, China.
Jiayou XingCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, Henan Province, China.
Guoyu YangKey Laboratory of Animal Biochemistry and Nutrition, Ministry of Agriculture and Rural Affairs, Zhengzhou, Henan Province 450046, China.
Lei ZengCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, Henan Province, China.
Jiang WangCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, Henan Province, China.
Beibei ChuCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, Henan Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retinoic acid (RA), derived from retinol (ROL), is integral to cell growth, differentiation, and organogenesis. It is known that RA can inhibit herpes simplex virus (HSV) replication, but the interactions between alphaherpesviruses and RA metabolism are unclear. Our present study revealed that alphaherpesvirus (HSV-1 and Pseudorabies virus, PRV) infections suppressed RA synthesis from ROL by activating P53, which increased retinol reductase 3 (DHRS3) expression-an enzyme that converts retinaldehyde back to ROL. This process depended on the virus-triggered DNA damage response, the degradation of class I histone deacetylases, and the subsequent hyperacetylation of histones H3 and H4. Counteracting DHRS3 or P53 enabled higher RA synthesis and reduced viral growth. RA enhanced antiviral defenses by promoting ABCA1- and ABCG1-mediated lipid efflux. Treatment with the retinoic acid receptor (RAR) agonist palovarotene protected mice from HSV-1 infection, thus providing a potential therapeutic strategy against viral infections.

Indexed as

Cell biologyVirology

Identifiers

PMID38989466
PMCPMC11233922

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.