Evidence map›Paper›PMID 38989285›Full record

ArticleFrontiers in immunology2024

Microbiome-derived bacterial lipids regulate gene expression of proinflammatory pathway inhibitors in systemic monocytes.

Saki Mihori, Frank Nichols, Anthony Provatas, Alyssa Matz, Beiyan Zhou, Christopher N Blesso, Hunter Panier, Lauren Daddi, Yanjiao Zhou, Robert B Clark

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Saki MihoriDepartment of Immunology, UConn Health, Farmington, CT, United States.
Frank NicholsDepartment of Periodontology, UConn Health, Farmington, CT, United States.
Anthony ProvatasCenter for Environmental Sciences and Engineering, Institute of the Environment, University of Connecticut, Storrs, CT, United States.
Alyssa MatzDepartment of Immunology, UConn Health, Farmington, CT, United States.
Beiyan ZhouDepartment of Immunology, UConn Health, Farmington, CT, United States.
Christopher N BlessoDepartment of Nutritional Sciences, University of Connecticut, Storrs, CT, United States.
Hunter PanierDepartment of Medicine, UConn Health, Farmington, CT, United States.
Lauren DaddiDepartment of Medicine, UConn Health, Farmington, CT, United States.
Yanjiao ZhouDepartment of Medicine, UConn Health, Farmington, CT, United States.
Robert B ClarkDepartment of Immunology, UConn Health, Farmington, CT, United States.

Funding

MiR-150 regulated adiose tissue B cells in obesityR01DK121805 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI VELLA, ANTHONY T, ZHOU, BEIYAN · 2020 to 2024
$2.0M
ASCVD risk assessment in T2DM facilitated by novel computational immunology programsR01HL172239 · NHLBI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Anthony T Vella, Beiyan Zhou · 2024 to 2026
$1.6M
Porphyromonas gingivalis glycine lipids mediate bone loss through TLR2R01DE027642 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI NICHOLS, FRANK C · 2019 to 2022
$1.6M
NHLBI NIH HHS R01 HL172239NIDCR NIH HHS R01 DE027642NIDDK NIH HHS R01 DK121805
6 · The paper itself

Abstract

How the microbiome regulates responses of systemic innate immune cells is unclear. In the present study, our purpose was to document a novel mechanism by which the microbiome mediates crosstalk with the systemic innate immune system. We have identified a family of microbiome

Indexed as

MonocytesSignal TransductionAnimalsCytokinesFemaleGene Expression RegulationImmunity, InnateInflammationInterferon Regulatory FactorsLipidsLipopeptidesMaleMembrane GlycoproteinsMiceMice, Inbred C57BLMicrobiotaCytokinesInterferon Regulatory FactorsLipidsLipopeptidesMembrane GlycoproteinsNF-kappa BReceptors, ImmunologicToll-Like Receptor 2bacterial lipidsgene expressioninhibitorsinnate immunitymicrobiomeproinflammatory pathwaysTLR

Identifiers

PMID38989285
PMCPMC11233717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.