Evidence map›Paper›PMID 38989065›Full record

ArticleIndian journal of sexually transmitted diseases and AIDS

Anti-retroviral therapy adherence in India (2012-18): A systematic review and meta-analysis.

Saurav Basu, Yamini Marimuthu, Suneela Garg, Velusamy Saravanakumar, Balasubramanian Ganesh

Abstract read
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Article in Indian journal of sexually transmitted diseases and AIDS. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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0cells of the map it votes in
4citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Saurav BasuDepartment of Community Medicine, Maulana Azad Medical College, New Delhi, India.
Yamini MarimuthuDepartment of Community and Family Medicine, AIIMS, Mangalagiri, Andhra Pradesh, India.
Suneela GargDepartment of Community Medicine, Maulana Azad Medical College, New Delhi, India.
Velusamy SaravanakumarICMR-National Institute of Epidemiology, Chennai, Tamil Nadu, India.
Balasubramanian GaneshICMR-National Institute of Epidemiology, Chennai, Tamil Nadu, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: India has 2.1 million people living with HIV/AIDS (PLHIV). The objective of this study was to ascertain the extent of anti-retroviral therapy (ART) adherence and reasons for nonadherence among PLHIV in India. Methods: We conducted a systematic review and meta-analysis using the following criteria: (1) Observational or experimental studies conducted in India and (2) English language studies. Published during January 2012-June 2018 with data collection during the same period (3). 95% ART adherence rate (primary outcome). We reviewed bibliographic databases (PubMed, Scopus) and extracted relevant data. The forest plot was used to display the meta-analysis results. Analyses were performed in Stata 14 using the "Metaprop_one" function. Results: A total of 511 records were identified after removing duplicates, 59 full-texts were screened of which 15 studies were included in the meta-analysis. Only one study was conducted in rural India, with <95% adherence reported by all its participants. The PLHIV reported several reasons for their ART nonadherence including forgetfulness (8/15), running out of pills (3/15), distance from the health center and associated travel (2/15), alcohol abuse (3/15), concealment of HIV status from family (2/15, felt stigma (2/15), depressive symptoms (2/15), and fear of side-effects (2/15). The overall pooled estimate of ART adherence was 54.1% (95% confidence interval [CI] 27%-81%), while among facility-based studies, the ≥95% adherence rate was significant higher. 62% (95% CI 46%-0.78%). Conclusions: Despite the universal provision of free of cost ART to all PLHIV in government health facilities in India, suboptimal adherence to treatment persists in nearly half of these patients.

Indexed as

Adherenceanti-retroviral therapyIndia

Identifiers

PMID38989065
PMCPMC11233045

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