ArticleISME communications2024
Evolutionary and co-evolutionary phage training approaches enhance bacterial suppression and delay the emergence of phage resistance.
Article in ISME communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Experimental evolution of phage K enhances antibacterial activity against USA300 MRSA in lung infection models.Emerging microbes & infections · 2026Article
- Predation in microbial communities: gradients of nutritive killing.Nature reviews. Microbiology · 2026Review
- Directed evolution of phage Romulus in biofilm-embeddedBiofilm · 2026Article
- Phage and endolysin-based inhibition ofFrontiers in cellular and infection microbiology · 2026Review
- Whole-Genome Sequencing and Functional Characterization of a NovelInternational journal of molecular sciences · 2025Article
- Experimental phage evolution results in expanded host ranges against antibiotic resistant Klebsiella pneumoniae isolates.Nature communications · 2025Article
- [Regulation of phage therapy medicinal products: developments, challenges and opportunities].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2025Review
- Weberviruses are gut-associated phages that infect Klebsiella spp.FEMS microbiology ecology · 2025Article
- Regulation of phage therapy medicinal products: developments, challenges, and opportunities.Frontiers in cellular and infection microbiology · 2025Review
- Phage therapy to treat cystic fibrosisFrontiers in microbiology · 2024Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of phage resistance by bacteria is a major barrier that impedes the therapeutic use of phages. Phage training has been proposed as a novel tool that harnesses the evolutionary potential of phages to improve phage infectivity. Both evolutionary and co-evolutionary phage training models have been previously reported to train phages. However, both of these phage training models have been reported able to effectively suppress the emergence of phage-resistant bacteria mutants, thus presenting a contradictory phenomenon. Therefore, in this study, we set out to systematically compare the effectiveness of both evolutionary and co-evolutionary phage training models with regard to phage physiology, infectivity, and genotype. To this end, a natural lytic phage capable of infecting a
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