Evidence map›Paper›PMID 38988457›Full record

ArticleFocus (American Psychiatric Publishing)2024

Why Don't You Just Eat? Neuroscience and the Enigma of Eating Disorders.

Claire K Pinson, Guido K W Frank

Abstract read
In one paragraph

Article in Focus (American Psychiatric Publishing), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Claire K PinsonSchool of Medicine, University of California, San Diego, California (Pinson); Department of Psychiatry, University of California, San Diego, UCSD Eating Disorders Center for Treatment and Research, and Rady Children's Hospital, San Diego, California (Frank).
Guido K W FrankSchool of Medicine, University of California, San Diego, California (Pinson); Department of Psychiatry, University of California, San Diego, UCSD Eating Disorders Center for Treatment and Research, and Rady Children's Hospital, San Diego, California (Frank).

Funding

Taste reward circuits and prediction error define eating disorder psychopathologyR01MH103436 · NIMH · UNIVERSITY OF COLORADO DENVER · PI STODDARD, JOEL JOHNSON · 2014 to 2018
$2.0M
Brain Reward Circuits and Computational Modeling in Adolescent Anorexia NervosaR01MH096777 · NIMH · UNIVERSITY OF COLORADO DENVER · PI FRANK, GUIDO KW · 2012 to 2016
$1.5M
NIMH NIH HHS R01 MH096777NIMH NIH HHS R01 MH103436
6 · The paper itself

Abstract

Eating disorders are severe psychiatric illnesses that are associated with high mortality. Research has identified environmental, psychological, and biological risk factors that could contribute to the psychopathology of eating disorders. Nevertheless, the patterns of self-starvation, binge eating, and purging behaviors are difficult to reconcile with the typical mechanisms that regulate appetite, hunger, and satiety. Here, the authors present a neuroscience and human brain imaging-based model to help explain the detrimental and often persistent behavioral patterns seen in individuals with eating disorders and why it is so difficult to overcome them. This model incorporates individual motivations to change eating, fear conditioning, biological adaptations of the brain and body, and the development of a vicious cycle that drives the individual to perpetuate those behaviors. This knowledge helps to explain these illnesses to patients and their families, and to develop more effective treatments, including biological interventions.

Indexed as

Anorexia NervosaBulimia NervosaCircuitryDopamineFear ConditioningFeeding and Eating Disorders

Identifiers

PMID38988457
PMCPMC11231469

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.