Evidence map›Paper›PMID 38988257›Full record

ArticleJournal of extracellular vesicles2024

Ceramide-mediated orchestration of oxidative stress response through filopodia-derived small extracellular vesicles.

Zainuddin Quadri, Ahmed Elsherbini, Simone M Crivelli, Salim S El-Amouri, Priyanka Tripathi, Zhihui Zhu, Xiaojia Ren, Liping Zhang, Stefka D Spassieva, Mariana Nikolova-Karakashian and 1 more

Abstract read
In one paragraph

Article in Journal of extracellular vesicles, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. A Novel Reporter Mouse for Astrocyte-Derived Extracellular Vesicles Reveals Enrichment of Cargo at Neuronal Mitochondria.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zainuddin QuadriDepartment of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Ahmed ElsherbiniDepartment of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Simone M CrivelliDepartment of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Salim S El-AmouriDepartment of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Priyanka TripathiDepartment of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Zhihui ZhuDepartment of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Xiaojia RenDepartment of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Liping ZhangDepartment of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Stefka D SpassievaDepartment of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Mariana Nikolova-KarakashianDepartment of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Erhard BieberichDepartment of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA.ORCID https://orcid.org/0000-0001-8490-7395

Funding

Function of ceramide in extracellular vesicle-mediated neurodegenerative diseaseRF1AG078338 · NIA · UNIVERSITY OF KENTUCKY · PI BIEBERICH, ERHARD · 2022 to 2025
$2.6M
Regulation of Microglial Activation State by a Lipid TransporterR01AG064234 · NIA · UNIVERSITY OF KENTUCKY · PI BIEBERICH, ERHARD · 2020 to 2024
$1.9M
Novel experimental models to study the effect of extracellular vesicles on neuronsR21AG078601 · NIA · UNIVERSITY OF KENTUCKY · PI BIEBERICH, ERHARD · 2022 to 2022
$421k
TBI-induced exosome release accelerates Alzheimer's disease pathologyI01BX003643 · VA · VA MEDICAL CENTER - LEXINGTON, KY · PI BIEBERICH, ERHARD · 2020 to 2023
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BLRD VA I01 BX003643NIA NIH HHS R01 AG064234NIA NIH HHS R21 AG078601NIA NIH HHS RF1 AG078338NIH HHS R01AG064234NIH HHS R21AG078601NIH HHS RF1AG078338US Department of Veteran Affairs I01BX003643
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are shed from the plasma membrane, but the regulation and function of these EVs remain unclear. We found that oxidative stress induced by H

Indexed as

CeramidesExtracellular VesiclesOxidative StressPseudopodiaSphingomyelin PhosphodiesteraseCell MembraneHeLa CellsHumansHydrogen PeroxideCeramidesHydrogen PeroxideSMPD3 protein, humanSphingomyelin Phosphodiesteraseceramidefilopodiamicrovesiclesmitochondriaoxidative stresssphingomyelinases

Identifiers

PMID38988257
PMCPMC11237349

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.