Evidence map›Paper›PMID 38988250›Full record

ArticleJournal of medicinal chemistry2024

Structure-Activity Relationship Studies of Aryl Sulfoxides as Reversible Monoacylglycerol Lipase Inhibitors.

Ming Jiang, Mirjam C W Huizenga, Florian Mohr, Avand Amedi, Renze Bakker, Richard J B H N van den Berg, Hui Deng, Tom van der Wel, Constant A A van Boeckel, Mario van der Stelt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ming JiangDepartment of Molecular Physiology, Leiden University and Oncode Institute, Leiden 2333 CC, Netherlands.
Mirjam C W HuizengaDepartment of Molecular Physiology, Leiden University and Oncode Institute, Leiden 2333 CC, Netherlands.ORCID 0000-0001-8313-0019
Florian MohrDepartment of Molecular Physiology, Leiden University and Oncode Institute, Leiden 2333 CC, Netherlands.
Avand AmediDepartment of Molecular Physiology, Leiden University and Oncode Institute, Leiden 2333 CC, Netherlands.
Renze BakkerDepartment of Molecular Physiology, Leiden University and Oncode Institute, Leiden 2333 CC, Netherlands.
Richard J B H N van den BergDepartment of Bio-organic Synthesis, Leiden University, Leiden 2333 CC, Netherlands.
Hui DengDepartment of Molecular Physiology, Leiden University and Oncode Institute, Leiden 2333 CC, Netherlands.
Tom van der WelDepartment of Molecular Physiology, Leiden University and Oncode Institute, Leiden 2333 CC, Netherlands.
Constant A A van BoeckelDepartment of Molecular Physiology, Leiden University and Oncode Institute, Leiden 2333 CC, Netherlands.
Mario van der SteltDepartment of Molecular Physiology, Leiden University and Oncode Institute, Leiden 2333 CC, Netherlands.ORCID 0000-0002-1029-5717

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monoacylglycerol lipase (MAGL) is the key enzyme for the hydrolysis of endocannabinoid 2-arachidonoylglycerol (2-AG). The central role of MAGL in the metabolism of 2-AG makes it an attractive therapeutic target for a variety of disorders, including inflammation-induced tissue injury, pain, multiple sclerosis, and cancer. Previously, we reported

Indexed as

Enzyme InhibitorsMonoacylglycerol LipasesSulfoxidesAnimalsHigh-Throughput Screening AssaysHumansMicrosomes, LiverStructure-Activity RelationshipEnzyme InhibitorsMonoacylglycerol LipasesSulfoxides

Identifiers

PMID38988250
PMCPMC11284796

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.