ArticlemBio2024
Metabolic remodeling by RNA polymerase gene mutations is associated with reduced β-lactam susceptibility in oxacillin-susceptible MRSA.
Abstract read
In one paragraph
Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Methicillin-resistant Staphylococcus aureus.Nature reviews. Disease primers · 2026Review
- Mutations in RNA polymerase that drive the emergence of antibiotic resistance.Current opinion in microbiology · 2026Review
- Constrained RNA polymerase mutational pathways distinguish corallopyronin A resistance from rifampicin resistance in staphylococci.Scientific reports · 2026Article
- Berberine modulates virulence gene expression in methicillin-resistantFrontiers in microbiology · 2026Article
- Article
- Antimicrobial Resistance and Risk Factors of Canine Bacterial Skin Infections.Pathogens (Basel, Switzerland) · 2025Article
- A mutation in RNA polymerase imparts resistance to β-lactams by preventing dysregulation of amino acid and nucleotide metabolism.Cell reports · 2025Article
- RpoB H481Y Rifampicin Resistance Mutation-Associated Oxidative Stress Sensitivity Reduces the Virulence of Staphylococcus aureus.Microbiology and immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors.
Shinya WatanabeDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.ORCID 0000-0003-3932-8575
Chijioke A NsoforDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Kanate ThitiananpakornDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Xin-Ee TanDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.ORCID 0000-0001-7847-2583
Yoshifumi AibaDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Remi TakenouchiSchool of Medicine, Jichi Medical University, Tochigi, Japan.
Kotaro KigaDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.ORCID 0000-0002-0248-6951
Teppei SasaharaDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Kazuhiko MiyanagaDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Srivani VeeranarayananDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Yuzuki ShimamoriDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Adeline Yeo Syin LianDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Thuy Minh NguyenDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Huong Minh NguyenDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Ola AlessaDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Geoffrey Peterkins KumwendaDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Sarangi JayathilakeDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Jastin Edrian Cocuangco RevillezaDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Priyanka BaranwalDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Yutaro NishikawaDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Feng-Yu LiDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Tomofumi KawaguchiDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Sowmiya SankaranarayananDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Mahmoud ArbaahDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Yuancheng ZhangDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
ManiruzzamanDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Yi LiuDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Hossain SarahDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Junjie LiDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Takashi SuganoDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Thi My Duyen HoDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Anujin BatboldDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Tergel NayanjinDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Longzhu CuiDivision of Bacteriology, Department of Infection and Immunity, Jichi Medical University, Tochigi, Japan.
Funding
Japan Agency for Medical Research and Development (AMED) JP20fk0108134Japan Agency for Medical Research and Development (AMED) JP21fk0108496Japan Agency for Medical Research and Development (AMED) JP21fk0108497Japan Agency for Medical Research and Development (AMED) JP21gm1610002Japan Agency for Medical Research and Development (AMED) JP21wm0325022Japan Agency for Medical Research and Development (AMED) JP22ae0121045MEXT | Japan Society for the Promotion of Science (JSPS) 19K08960MEXT | Japan Society for the Promotion of Science (JSPS) 20F20104MEXT | Japan Society for the Promotion of Science (JSPS) 21K19488MEXT | Japan Society for the Promotion of Science (JSPS) 22K19386MEXT | Japan Society for the Promotion of Science (JSPS) L21543Takeda Science Foundation (TSF)
Abstract
The emergence of oxacillin-susceptible methicillin-resistant IMPORTANCE: The emergence of oxacillin-susceptible methicillin-resistant
Indexed as
Anti-Bacterial AgentsDNA-Directed RNA PolymerasesMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsOxacillinBacterial Proteinsbeta-LactamsCell WallHumansMetabolomicsMutationMutation, MissenseAnti-Bacterial AgentsBacterial Proteinsbeta-LactamsDNA-Directed RNA PolymerasesOxacillinantimicrobial resistantbeta-lactamsMRSAOS-MRSAoxacillinRNA polymerasesrpoBCStaphylococcus aureus
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.