Evidence map›Paper›PMID 38988201›Full record

ReviewPlant & cell physiology2025

Beyond the Standard GWAS-A Guide for Plant Biologists.

Pieter Clauw, Thomas James Ellis, Hai-Jun Liu, Eriko Sasaki

Abstract readReview
In one paragraph

Review in Plant & cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Frontiers in plant science · 2026
    Article
  14. Functional Study ofPlants (Basel, Switzerland) · 2025
    Article
  15. Review
  16. Article
  17. Large-scale identification and association analysis of wheat grain weight genes using rice orthologs.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pieter ClauwGregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences, Vienna BioCenter (VBC), Dr. Bohr-Gasse 3, Vienna 1030, Austria.ORCID 0000-0002-9677-8727
Thomas James EllisGregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences, Vienna BioCenter (VBC), Dr. Bohr-Gasse 3, Vienna 1030, Austria.ORCID 0000-0002-8511-0254
Hai-Jun LiuGregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences, Vienna BioCenter (VBC), Dr. Bohr-Gasse 3, Vienna 1030, Austria.ORCID 0000-0001-7717-893X
Eriko SasakiFaculty of Science, Kyushu University, 744, Motooka, Nishi-ku, Fukuoka 819-0395, Japan.ORCID 0000-0002-0878-364X

Funding

Japan Society for the Promotion of Science 20K22671 21H02538
6 · The paper itself

Abstract

Classic genome-wide association studies (GWAS) look for associations between individual single-nucleotide polymorphisms (SNPs) and phenotypes of interest. With the rapid progress of high-throughput genotyping and phenotyping technologies, GWAS have become increasingly powerful for detecting genetic determinants and their molecular mechanisms underpinning natural phenotypic variation. However, GWAS frequently yield results with neither expected nor promising loci, nor any significant associations. This is often because associations between SNPs and a single phenotype are confounded, for example with the environment, other traits or complex genetic structures. Such confounding can mask true genotype-phenotype associations, or inflate spurious associations. To address these problems, numerous methods have been developed that go beyond the standard model. Such advanced GWAS models are flexible and can offer improved statistical power for understanding the genetics underlying complex traits. Despite this advantage, these models have not been widely adopted and implemented compared to the standard GWAS approach, partly because this literature is diverse and often technical. In this review, our aim is to provide an overview of the application and the benefits of various advanced GWAS models for handling complex traits and genetic structures, targeting plant biologists who wish to carry out GWAS more effectively.

Indexed as

Genome-Wide Association StudyPlantsGenome, PlantGenotypePhenotypePolymorphism, Single NucleotideAdvanced GWASComplex traitsGenetic architectureMultiple traits

Identifiers

PMID38988201
PMCPMC12085090

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.