ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Cerebral arteriolosclerosis, lacunar infarcts, and cognition in older Black adults.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Periodontal Disease Independently Associated With White Matter Hyperintensity Volume: A Measure of Cerebral Small Vessel Disease.Neurology open access · 2025Article
- Association of an in vivo classifier for ARTerioloSclerosis (ARTS) with cortical thickness and cognition in older adults.Neurobiology of aging · 2025Article
- ARTS is associated with vascular risk factors, MCI, dementia, and stroke.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Osteoporosis Is Associated with Cerebral Small Vessel Disease in Stroke-Free Individuals: A Retrospective Observational Study.Geriatrics (Basel, Switzerland) · 2025Article
- Cerebral arteriolosclerosis, lacunar infarcts, and cognition in older Black adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
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Abstract
introductionOlder Black adults are at risk of cerebral small vessel disease (CSVD), which contributes to dementia risk. Two subtypes of CSVD, arteriolosclerosis and ischemic lacunar infarcts, have been independently linked to lower cognition and higher dementia risk, but their combined effects on cognition in older Black adults are unclear.
methodsMixed models were used to examine the associations of in vivo measures of arteriolosclerosis (ARTS) and ischemic lacunar infarcts to cognitive level and change in 370 older Black adults without dementia.
resultsModeled together, higher ARTS load accounted for lower levels of global cognition, episodic memory, semantic memory, and perceptual speed, whereas higher infarct load accounted for lower levels of working memory. There were no associations with rate of cognitive change. DISCUSSION: Both arteriolosclerosis and ischemic infarcts impact the cognitive health of older Black adults, but arteriolosclerosis affects cognition more broadly and offers promise as an in vivo biomarker of dementia risk. HIGHLIGHTS: Older Black adults are at risk of cerebral small vessel disease (CSVD) and dementia. Examined magnetic resonance imaging-derived measure of arteriolosclerosis (ARTS), infarcts, and cognition. ARTS load was widely associated with lower cognition after adjusting for infarct load. Infarct load was specifically associated with lower complex attention. More within-Black in vivo studies of CSVD subtypes and cognition are needed.
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