Evidence map›Paper›PMID 38987904›Full record

ArticleThe Journal of comparative neurology2024

Sexual Dimorphism of Spinal Neural Circuits Controlling the Mouse External Urethral Sphincter With and Without Spinal Cord Injury.

Sergei Karnup, Mamoru Hashimoto, Kang Jun Cho, Jonathan Beckel, William de Groat, Naoki Yoshimura

Abstract read
In one paragraph

Article in The Journal of comparative neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sergei KarnupDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-7757-5046
Mamoru HashimotoDepartment of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Kang Jun ChoDepartment of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Jonathan BeckelDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-1390-2292
William de GroatDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Naoki YoshimuraDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-4185-323X

Funding

Intraspinal circuits supporting synergy between the bladder and urethral sphincter in miceR01DK129194 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KARNUP, SERGEI V, YOSHIMURA, NAOKI · 2021 to 2024
$1.4M
NIDDK NIH HHS R01 DK129194NIH HHS 1R01 DK129194
6 · The paper itself

Abstract

Spinal cord injury (SCI) disrupts coordination between the bladder and the external urinary sphincter (EUS), leading to transient or permanent voiding impairment, which is more severe in males. Male versus female differences in spinal circuits related to the EUS as well as post-SCI rewiring are essential for understanding of sex-/gender-specific impairments and possible recovery mechanisms. To quantitatively assess differences between EUS circuits in males versus females and in spinal intact (SI) versus SCI animals, we retrogradely traced and counted EUS-related neurons. In transgenic ChAT-GFP mice, motoneurons (MNs), interneurons (INs), and propriospinal neurons (PPNs) were retrogradely trans-synaptically traced with PRV614-red fluorescent protein (RFP) injected into EUS. EUS-MNs in dorsolateral nucleus (DLN) were separated from other GFP

Indexed as

Mice, TransgenicSex CharacteristicsSpinal Cord InjuriesUrethraAnimalsDisease Models, AnimalFemaleMaleMiceMice, Inbred C57BLMotor NeuronsNeural PathwaysSpinal CordChAT‐EGFP mouseexternal urethral sphincterinterneuronsmotoneuronspseudorabies virusspinal cord injury

Identifiers

PMID38987904
PMCPMC11260501

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.