Evidence map›Paper›PMID 38987786›Full record

ArticleTrials2024

Comparison of the effect of combined usage of povidone-iodine irrigation and topical vancomycin powder to the use of povidone-iodine irrigation alone on the periprosthetic joint infection incidence rate in patients undergoing primary total hip and knee arthroplasty: a protocol for multicenter prospective randomized clinical trial.

Michał Kułakowski, Karol Elster, Mateusz Szymczak, Paweł Ślęczka, Mariusz Baumgart, Aleksandra Królikowska, Paweł Reichert

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05972603 (Can Topical Vancomycin Prevent Periprosthetic Joint Infection in Primary Hip and Knee Arthroplasty? Multicenter Randomized Controlled Trial), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05972603 naunknown statusnot on this map

Can Topical Vancomycin Prevent Periprosthetic Joint Infection in Primary Hip and Knee Arthroplasty? Multicenter Randomized Controlled Trial

TypeinterventionalSponsorIndependent Public Healthcare Center in RypinRan2022 to 2024Enrolled1,000ConditionsOsteoarthritis, Knee, Osteoarthritis, Hip, Rheumatoid Arthritis, Avascular Necrosis of HipArms1.0 g Vancomycin powder into the wound, 0,35% povidone-iodine solution lavage
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michał KułakowskiOrthopaedic and Trauma Surgery Department, Independent Public Healthcare Center in Rypin, Rypin, Poland.
Karol ElsterOrthopaedic and Trauma Surgery Department, Independent Public Healthcare Center in Rypin, Rypin, Poland.
Mateusz SzymczakOrthopaedic and Trauma Surgery Department, Independent Public Healthcare Center in Rypin, Rypin, Poland.
Paweł ŚlęczkaTrauma and Orthopedic Surgery Department, Independent Public Healthcare Center in Myslenice, Myslenice, Poland.
Mariusz BaumgartDepartment of Normal Anatomy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Toruń, Poland.
Aleksandra KrólikowskaErgonomics and Biomedical Monitoring Laboratory, Department of Physiotherapy, Faculty of Health Sciences, Wroclaw Medical University, Wroclaw, Poland. aleksandra.krolikowska@umw.edu.pl.ORCID http://orcid.org/0000-0002-6283-5500
Paweł ReichertDepartment of Orthopedics, Traumatology and Hand Surgery, Faculty of Medicine, Wroclaw Medical University, Wroclaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWith the increasing number of joint replacement surgeries, periprosthetic joint infection (PJI) has become a significant concern in orthopedic practice, making research on PJI prevention paramount. Therefore, the study will aim to compare the effect of combined usage of povidone-iodine and topical vancomycin powder to the use of povidone-iodine alone on the PJI incidence rate in patients undergoing primary total hip (THA) and total knee arthroplasty (TKA).

methodsThe prospective randomized clinical trial will be conducted in two independent voivodeship hospitals with extensive experience in lower limb arthroplasties. The studied material will comprise 840 patients referred to hospitals for primary THA or TKA. The patients will be randomly allocated to two equal groups, receiving two different interventions during joint replacement. In group I, povidone-iodine irrigation and consecutively topical vancomycin powder will be used before wound closure. In group II, only povidone-iodine lavage irrigation will be used before wound closure. The primary outcome will be the incidence rate of PJI based on the number of patients with PJI occurrence within 90 days after arthroplasty. The occurrence will be determined using a combined approach, including reviewing hospital records for readmissions and follow-up phone interviews with patients. The infection will be diagnosed based on Musculoskeletal Infection Society criteria. The chi-square test will be used to compare the infection rates between the two studied groups. Risk and odds ratios for the between-groups comparison purposes will also be estimated. Medical cost analysis will also be performed. DISCUSSION: A randomized clinical trial comparing the effect of combined usage of povidone-iodine irrigation and vancomycin powder to the use of povidone-iodine irrigation alone in preventing PJIs after primary arthroplasty is crucial to advancing knowledge in orthopedic surgery, improving patient outcomes, and guiding evidence-based clinical practices.

trial registrationClinicalTrials.gov NCT05972603 . Registered on 2 August 2023.

Indexed as

Administration, TopicalAnti-Bacterial AgentsAnti-Infective Agents, LocalArthroplasty, Replacement, HipArthroplasty, Replacement, KneePovidone-IodineProsthesis-Related InfectionsRandomized Controlled Trials as TopicTherapeutic IrrigationVancomycinHumansIncidenceMulticenter Studies as TopicPowdersProspective StudiesTreatment OutcomeAnti-Bacterial AgentsAnti-Infective Agents, LocalPovidone-IodinePowdersVancomycinArthroplastyOrthopedicsPeriprosthetic joint infectionPostoperative complicationsTotal hip replacementTotal knee replacement

Identifiers

PMID38987786
PMCPMC11234679

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.