ArticleNature2024
Single-cell atlas of the human brain vasculature across development, adulthood and disease.
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers.
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119citing papers in PubMed
–field-weighted citation impact
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Who cites it
119 citing papers in PubMed.
- Targeting KIT prevents brain arteriovenous malformations driven by ALK1-deficient angiogenic endothelial cells.The Journal of clinical investigation · 2026Article
- Engineered Microvascular Model of the Blood-Brain-Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma.Advanced healthcare materials · 2026Article
- Spatially resolved multiomics of human meningeal development reveal lineage and disease dynamics.Nature cell biology · 2026Article
- Spatial pattern-driven interpretable model and biological correlates in brain glioblastoma-lymphoma differentiation.iScience · 2026Article
- Article
- Small-molecule-induced neuron-specific hypoxia: recapitulating developmental angiogenesis for ischemic stroke therapy.Acta pharmacologica Sinica · 2026Article
- TopClust: Topological-based analysis of scRNA-seq data for data-driven identification of clusters and core cluster cells.Biophysical journal · 2026Article
- VINE-seq and MultiVINE-seq for single-nucleus and multiome profiling of the brain vasculature.Nature protocols · 2026Review
- Cell-to-Cell Signaling Networks at the Blood-Brain Barrier in Health and Disease.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Cellular and signalling mechanisms that regulate the blood-brain barrier.Nature reviews. Molecular cell biology · 2026Review
- CA-IV-directed small-molecule shuttle enables targeted brain delivery of biologics.Nature chemical biology · 2026Article
- Article
- Endothelial Cell TRIM47 Triggers Blood-Brain Barrier Disruption via CYLD Ubiquitination Degradation in an Intracerebral Hemorrhage Model.Neuroscience bulletin · 2026Article
- Cerebrovascular vulnerability and fibrosis in human brain aneurysms.Nature neuroscience · 2026Article
- A collaborative framework for uncovering molecular and cellular drivers of VCID: Foundations for future interventions in dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Single-Cell Analysis of Brain Arteriovenous Malformations Reveals Pro-Angiogenic Myeloid Programs.Brain sciences · 2026Article
- An Integrated Multi-omics Single Cell Atlas of the Human RPE and Choroid.bioRxiv : the preprint server for biology · 2026Article
- Heterogenous microglial reactivity contrasts with stable vascular transcriptional programs in mouse models of Alzheimer's, CADASIL, and Traumatic Brain Injury.Nature communications · 2026Article
- Advances in the Comprehensive Tree Shrew Brain Atlas.Biomolecules · 2026Review
- Friend or foe? Glial-vascular interactions in health and neurodegenerative disease.Pharmacological reviews · 2026Review
59 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
37 authors.
Thomas Wälchli *Group Brain Vasculature and Perivascular Niche, Division of Experimental and Translational Neuroscience, Krembil Brain Institute, Krembil Research Institute, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada. thomas.waelchli2@uzh.ch.ORCID 0000-0002-8961-6551
Moheb Ghobrial *Group Brain Vasculature and Perivascular Niche, Division of Experimental and Translational Neuroscience, Krembil Brain Institute, Krembil Research Institute, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Marc SchwabGroup Brain Vasculature and Perivascular Niche, Division of Experimental and Translational Neuroscience, Krembil Brain Institute, Krembil Research Institute, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Shigeki TakadaDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-2977-888X
Hang ZhongGroup Brain Vasculature and Perivascular Niche, Division of Experimental and Translational Neuroscience, Krembil Brain Institute, Krembil Research Institute, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Samuel SuntharalinghamGroup Brain Vasculature and Perivascular Niche, Division of Experimental and Translational Neuroscience, Krembil Brain Institute, Krembil Research Institute, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Sandra VetiskaDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Daymé Rodrigues GonzalezFunctional Genomics Center Zurich, ETH Zurich/University of Zurich, Zurich, Switzerland.
Ruilin WuDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Hubert RehrauerFunctional Genomics Center Zurich, ETH Zurich/University of Zurich, Zurich, Switzerland.ORCID 0000-0001-7612-9394
Anuroopa DineshThe Lunenfeld-Tanenbaum Research Institute, Mount Sinai Health System, Toronto, Ontario, Canada.ORCID 0000-0002-0062-8004
Kai YuDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Edward L Y ChenThe Lunenfeld-Tanenbaum Research Institute, Mount Sinai Health System, Toronto, Ontario, Canada.
Jeroen BisschopGroup Brain Vasculature and Perivascular Niche, Division of Experimental and Translational Neuroscience, Krembil Brain Institute, Krembil Research Institute, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-8652-9535
Fiona FarnhammerGroup Brain Vasculature and Perivascular Niche, Division of Experimental and Translational Neuroscience, Krembil Brain Institute, Krembil Research Institute, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-4149-8215
Ann MansurDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Joanna KaluckaDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Itay TiroshDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Luca RegliDivision of Neurosurgery, University Hospital Zurich, Zurich, Switzerland.ORCID 0000-0003-4639-4474
Karl SchallerDepartment of Neurosurgery, University of Geneva Medical Center & Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Karl FreiGroup of CNS Angiogenesis and Neurovascular Link, Neuroscience Center Zurich, University of Zurich and University Hospital Zurich, Zurich, Switzerland.
Troy KetelaThe Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
Mark BernsteinDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Paul KongkhamDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Peter CarmelietLaboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB & Department of Oncology, KU Leuven, Leuven, Belgium.ORCID 0000-0001-7961-1821
Taufik ValianteDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-3443-3790
Peter B DirksDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0001-5718-6465
Mario L SuvaDepartment of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-9898-5351
Gelareh ZadehDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-6637-4502
Viviane TabarDepartment of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-1284-1670
Ralph SchlapbachFunctional Genomics Center Zurich, ETH Zurich/University of Zurich, Zurich, Switzerland.
Hartland W JacksonThe Lunenfeld-Tanenbaum Research Institute, Mount Sinai Health System, Toronto, Ontario, Canada.ORCID 0000-0001-6423-2415
Katrien De BockLaboratory of Exercise and Health, Institute of Exercise and Health, Department of Health Sciences and Technology; Swiss Federal Institute of Technology (ETH Zurich), Zurich, Switzerland.ORCID 0000-0001-8232-4663
Jason E FishDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0003-0640-7277
Philippe P MonnierDepartment of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Gary D BaderThe Lunenfeld-Tanenbaum Research Institute, Mount Sinai Health System, Toronto, Ontario, Canada.ORCID 0000-0003-0185-8861
Ivan RadovanovicDivision of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MTR&D 3 - Network Guided Machine LearningP41GM103504 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IDEKER, TREY · 2012 to 2024
$17.3MNCI NIH HHS P30 CA008748NIGMS NIH HHS P41 GM103504
Abstract
A broad range of brain pathologies critically relies on the vasculature, and cerebrovascular disease is a leading cause of death worldwide. However, the cellular and molecular architecture of the human brain vasculature remains incompletely understood
Indexed as
BrainBrain NeoplasmsCentral Nervous System Vascular MalformationsEndothelial CellsFetusRNA-SeqSingle-Cell Gene Expression AnalysisAdultCell CommunicationFemaleHealthHLA-D AntigensHumansMaleHLA-D Antigens
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.