Evidence map›Paper›PMID 38987598›Full record

ArticleNature2024

Dissociable hindbrain GLP1R circuits for satiety and aversion.

Kuei-Pin Huang, Alisha A Acosta, Misgana Y Ghidewon, Aaron D McKnight, Milena S Almeida, Nathaniel T Nyema, Nicholas D Hanchak, Nisha Patel, Yenoukoume S K Gbenou, Alice E Adriaenssens and 2 more

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Amylin: A Multi-Functional Pancreatic Hormone-A Review.Diabetes, obesity & metabolism · 2026
    Review
  8. Article
  9. The critical role of gut-brain signalling in eating behaviour and obesity.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. The evolving landscape of obesity pharmacotherapy.Nature reviews. Drug discovery · 2026
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Functional segregation of body-brain signals in the area postrema.bioRxiv : the preprint server for biology · 2026
    Article

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kuei-Pin HuangMonell Chemical Senses Center, Philadelphia, PA, USA.
Alisha A AcostaMonell Chemical Senses Center, Philadelphia, PA, USA.
Misgana Y Ghidewon *Monell Chemical Senses Center, Philadelphia, PA, USA.
Aaron D McKnight *Monell Chemical Senses Center, Philadelphia, PA, USA.
Milena S AlmeidaMonell Chemical Senses Center, Philadelphia, PA, USA.ORCID 0000-0003-2262-0035
Nathaniel T NyemaMonell Chemical Senses Center, Philadelphia, PA, USA.
Nicholas D HanchakMonell Chemical Senses Center, Philadelphia, PA, USA.
Nisha PatelMonell Chemical Senses Center, Philadelphia, PA, USA.ORCID 0009-0008-9964-2826
Yenoukoume S K GbenouMonell Chemical Senses Center, Philadelphia, PA, USA.
Alice E AdriaenssensDepartment of Neuroscience, Physiology, and Pharmacology, University College London, London, UK.
Kevin A BoldingMonell Chemical Senses Center, Philadelphia, PA, USA.
Amber L AlhadeffMonell Chemical Senses Center, Philadelphia, PA, USA. aalhadeff@monell.org.

Funding

Harnessing sensory food circuits to influence feeding behaviorDP2AT011965 · NCCIH · MONELL CHEMICAL SENSES CENTER · PI ALHADEFF, AMBER L · 2021 to 2024
$2.6M
Unraveling the homeostatic and hedonic circuits underlying feeding behavior and obesityR01DK131558 · NIDDK · MONELL CHEMICAL SENSES CENTER · PI ALHADEFF, AMBER L · 2021 to 2025
$2.3M
Cortical odor processing for social recognitionR01DC020927 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI KEVIN A BOLDING · 2024 to 2026
$1.2M
INVESTIGATING THE GUT-BRAIN SIGNALING DYNAMICS REGULATING FOOD INTAKER00DK119574 · NIDDK · MONELL CHEMICAL SENSES CENTER · PI ALHADEFF, AMBER L · 2020 to 2022
$868k
Leica STELLARIS 5 Confocal MicroscopeS10OD030354 · OD · MONELL CHEMICAL SENSES CENTER · PI ALHADEFF, AMBER L · 2021 to 2021
$399k
NCCIH NIH HHS DP2 AT011965NIDCD NIH HHS R01 DC020927NIDDK NIH HHS R00 DK119574NIDDK NIH HHS R01 DK131558NIH HHS S10 OD030354
6 · The paper itself

Abstract

The most successful obesity therapeutics, glucagon-like peptide-1 receptor (GLP1R) agonists, cause aversive responses such as nausea and vomiting

Indexed as

Anti-Obesity AgentsAvoidance LearningGlucagon-Like Peptide-1 ReceptorGlucagon-Like Peptide-1 Receptor AgonistsNeural PathwaysRhombencephalonSatiety ResponseAnimalsArea PostremaEatingFemaleFoodGlucagon-Like Peptide 1MaleMiceMice, Inbred C57BLAnti-Obesity AgentsGlp1r protein, mouseGlucagon-Like Peptide 1Glucagon-Like Peptide-1 ReceptorGlucagon-Like Peptide-1 Receptor Agonists

Identifiers

PMID38987598
PMCPMC12519567

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.