ArticleNature2024
An enterococcal phage-derived enzyme suppresses graft-versus-host disease.
Registry-linked trialAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07791849 (Comparative Effect of Proton Pump Inhibitors and Gastric Mucosal Protective Agents on Acute Graft-versus-Host Disease Post-Transplantation), which is not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Effect of Proton Pump Inhibitors and Gastric Mucosal Protective Agents on Acute Graft-versus-Host Disease Post-Transplantation: A Prospective Randomized Controlled Trial
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Safety and efficacy of fecal microbial transplantation for the prevention and treatment of acute graft-versus-host disease: a meta-analysis.Frontiers in microbiology · 2026Pooled it
- Gut microbiome-enteric virus interactions: mechanisms, clinical implications, and translational directions.Journal of gastroenterology · 2026Review
- Designing immune reconstitution to prevent graft-versus-host disease: a novel therapeutic paradigm beyond T cell suppression.International journal of hematology · 2026Review
- Prophage-Derived Endolysin E1 Synergizes with Meropenem AgainstMicroorganisms · 2026Article
- Article
- Article
- High-resolution phage-host assignment through key proteins using large language models.Nature communications · 2026Article
- Pre-Administration of Akkermansia Muciniphila Prevents the Development of Severe Acute Graft-Versus-Host Disease in Systemic Organs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Gastro-Intestinal Microbiota in Haematology.Acta haematologica · 2026Review
- Autoimmune disease-associated pathobionts: mechanisms and therapeutic potential of phage-based approaches.Frontiers in immunology · 2026Review
- Recent perspectives on precision-targeting therapy against oral biofilm.Journal of oral microbiology · 2026Review
- The gut-bone marrow axis in acute leukemia: an evidence-graded review of microbiota-immune crosstalk and therapeutic implications.Frontiers in cellular and infection microbiology · 2026Review
- Phage enabled precision drug delivery: dual function platforms for therapeutics and genetic cargo transport.Frontiers in microbiology · 2026Review
- Advances in Understanding the Impact of Human Gut Microbiota on Chemotherapy-Induced Neutropenia.Biomedicines · 2025Review
- A Distinct Intestinal Domination Fingerprint in Patients Undergoing Allo-HSCT: Dynamics, Predictors and Implications on Clinical Outcomes.Journal of clinical medicine · 2025Article
- Human gut prophage landscape identifies a prophage-mediated fucosylation mechanism alleviating colitis.Nature communications · 2025Article
- Multidrug-ResistantVeterinary sciences · 2025Article
- Enterococcus proliferates via the phosphotransferase system in the disrupted gut microbiota after allogeneic haematopoietic stem cell transplantation.British journal of haematology · 2025Article
- Fecal microbiota transplantation for Crohn's disease-like intestinal lesions arising after allogeneic stem cell transplantation.International journal of hematology · 2025Article
- Gut microbiota and acute graft-versus-host disease.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Kosuke Fujimoto *Department of Immunology and Genomics, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.ORCID 0000-0002-2948-549X
Tetsuya Hayashi *Department of Immunology and Genomics, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.ORCID 0000-0002-0535-7098
Mako YamamotoDivision of Health Medical Intelligence, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Noriaki SatoDivision of Health Medical Intelligence, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.ORCID 0000-0001-7721-9359
Masaki ShimohigoshiDepartment of Immunology and Genomics, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Daichi MiyaokaDepartment of Immunology and Genomics, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Chieko YokotaDepartment of Immunology and Genomics, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Miki WatanabeDepartment of Immunology and Genomics, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Yuki HisakiDepartment of Immunology and Genomics, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Yukari KameiDepartment of Immunology and Genomics, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Yuki YokoyamaDepartment of Immunology and Genomics, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Takato YabunoDepartment of Immunology and Genomics, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.ORCID 0009-0007-6973-0828
Asao HiroseDepartment of Hematology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Mika NakamaeDepartment of Hematology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.ORCID 0000-0002-9200-4804
Hirohisa NakamaeDepartment of Hematology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.ORCID 0000-0003-4203-990X
Miho UematsuDepartment of Immunology and Genomics, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.ORCID 0009-0008-9282-9065
Shintaro SatoDepartment of Immunology and Genomics, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Kiyoshi YamaguchiDivision of Clinical Genome Research, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Yoichi FurukawaDivision of Clinical Genome Research, Institute of Medical Science, University of Tokyo, Tokyo, Japan.ORCID 0000-0003-0462-8631
Yukihiro AkedaDepartment of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan.
Masayuki HinoDepartment of Hematology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Seiya ImotoDivision of Health Medical Intelligence, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan. imoto@ims.u-tokyo.ac.jp.ORCID 0000-0002-2989-308X
Satoshi UematsuDepartment of Immunology and Genomics, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan. uematsu.satoshi@omu.ac.jp.ORCID 0000-0002-5347-6737
Funding
No grant is acknowledged in the PubMed record.
Abstract
Changes in the gut microbiome have pivotal roles in the pathogenesis of acute graft-versus-host disease (aGVHD) after allogenic haematopoietic cell transplantation (allo-HCT)
Indexed as
BacteriophagesEnterococcus faecalisGastrointestinal MicrobiomeGraft vs Host DiseaseAdultAgedAnimalsAnti-Bacterial AgentsBiofilmsDrug Resistance, BacterialDysbiosisFecesFemaleGerm-Free LifeHematopoietic Stem Cell TransplantationHumansAnti-Bacterial AgentsPerforin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT07791849ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.