ArticleNature2024
A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection.
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In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Incidence and risk factors for hepatitis B virus reactivation in kidney transplant recipients: a systematic review and meta-analysis.BMC nephrology · 2026Pooled it
- The load of hepatitis B virus reduces the immune checkpoint inhibitors efficiency in hepatocellular carcinoma patients.Frontiers in immunology · 2024Pooled it
- Inducible cAMP Early Repressor Limits Glycolytic Programming in Regulatory T Cells and Supports Control of Inflammatory Colitis.European journal of immunology · 2026Article
- A Distinct Immune Signature Characterizes Cirrhosis in Ethiopian Individuals With Chronic HBV Infection.Alimentary pharmacology & therapeutics · 2026Article
- Liver sinusoidal endothelial cells in liver diseases and hepatocellular carcinoma: molecular mechanisms, physiology, and therapies.Molecular biomedicine · 2026Review
- Review
- Metabolically and epigenetically reprogrammed splenic TRNP1Nature genetics · 2026Article
- Association between changes in HBsAb levels and hepatic adverse events after HBsAg clearance in non-cirrhotic chronic hepatitis B patients.BMC infectious diseases · 2026Observational
- Engineering a dual-antigen mRNA vaccine to restore immune control in chronic hepatitis B.Nature communications · 2026Article
- β-Adrenergic receptors as immunomodulators in T cells: mechanisms of neuroimmune crosstalk and pathophysiological implications.Molecular medicine (Cambridge, Mass.) · 2026Review
- HBV-driven expansion of CXCR6Innovation (Cambridge (Mass.)) · 2026Article
- Monocyte-derived IL-1β predicts and promotes HBsAg decline in chronic hepatitis B patients under nucleoside analogue therapy.Hepatology communications · 2026Article
- Spatial-quantitative profiling of intrahepatic HBsAg heterogeneity and clustered distribution in chronic HBV infection.JHEP reports : innovation in hepatology · 2026Article
- Single-cell transcriptomics reveals heterogeneity and immune microenvironment in lymphatic metastasis of head and neck squamous cell carcinoma.Genes and immunity · 2026Article
- β-hydroxybutyrate potentiates anti-tumor immunity by modulating cytotoxic CD8Cancer immunology, immunotherapy : CII · 2026Article
- Article
- T cell adaptation in chronic infections and tumors.Cellular & molecular immunology · 2026Review
- Peptide hormones and bile acids shaping immune tolerance of the liver: implications and applications.Protein & cell · 2026Review
- T-Cell Profiles in HBV Functional Cure and People Living With HIV: Known Knowns, Known Unknowns, and Unknown Unknowns.Current HIV/AIDS reports · 2026Review
- Extensive evolution and T cell escape by SARS-CoV-2 in a 2.5-year persistent infection of an immunocompromised host.iScience · 2026Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
56 authors.
Miriam Bosch *Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.
Nina Kallin *Institute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.
Sainitin DonakondaInstitute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.ORCID 0000-0003-3216-8759
Jitao David ZhangRoche Pharmaceutical Research and Early Development (pRED), Roche Innovation Center Basel, Basel, Switzerland.ORCID 0000-0002-3085-0909
Hannah WinterstellerInstitute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.ORCID 0000-0003-2232-333X
Silke HegenbarthInstitute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.
Kathrin HeimThird Department of Medicine, University Hospital Freiburg, Freiburg, Germany.
Carlos RamirezHealth Data Science Unit, Biomedical Genomics Group, Bioquant, Faculty of Medicine Heidelberg, Heidelberg, Germany.
Anna FürstInstitute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.
Elias Isaac LattoufDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4765-6811
Martin FeuerherdDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5272-6503
Sutirtha ChattopadhyayInstitute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.
Nadine KumpesaRoche Pharmaceutical Research and Early Development (pRED), Roche Innovation Center Basel, Basel, Switzerland.
Vera GriesserRoche Pharmaceutical Research and Early Development (pRED), Roche Innovation Center Basel, Basel, Switzerland.
Jean-Christophe HoflackRoche Pharmaceutical Research and Early Development (pRED), Roche Innovation Center Basel, Basel, Switzerland.
Juliane Siebourg-PolsterRoche Pharmaceutical Research and Early Development (pRED), Roche Innovation Center Basel, Basel, Switzerland.ORCID 0000-0002-1759-3223
Carolin MoglerInstitute of Pathology, School of Medicine and Health, TUM, Munich, Germany.ORCID 0000-0003-3400-7254
Leo SwadlingDivision of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.ORCID 0000-0002-0537-6715
Laura J PallettDivision of Infection and Immunity, Institute of Immunity and Transplantation, University College London, London, UK.ORCID 0000-0002-4161-9462
Philippa MeiserInstitute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.
Katrin ManskeInstitute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.
Gustavo P de AlmeidaInstitute of Immunology and Animal Physiology, School of Life Science, TUM, Munich, Germany.ORCID 0000-0002-2424-9818
Anna D KosinskaInstitute of Virology, School of Medicine and Health, TUM, Munich, Germany.
Ioana SanduInstitute of Microbiology, ETH Zürich, Zürich, Switzerland.
Annika SchneiderInstitute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.
Vincent SteinbacherInstitute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.
Yan TengInstitute of Virology, School of Medicine and Health, TUM, Munich, Germany.
Julia SchnabelInstitute of Machine Learning and Biomedical Imaging, Helmholtz Zentrum Munich, Munich, Germany.
Fabian TheisInstitute of Computational Biology, TUM, Munich, Germany.ORCID 0000-0002-2419-1943
Adam J GehringToronto Centre for Liver Disease and Toronto General Hospital Research Institute, Toronto, Ontario, Canada.
Andre BoonstraDepartment of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Harry L A JanssenDepartment of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Michiel VandenboschInstitute of Multimodal Imaging, University of Maastricht, Maastricht, The Netherlands.ORCID 0000-0002-0427-416X
Eva CuypersInstitute of Multimodal Imaging, University of Maastricht, Maastricht, The Netherlands.ORCID 0000-0002-6411-2461
Rupert ÖllingerInstitute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TUM, Munich, Germany.ORCID 0000-0002-2292-5982
Thomas EngleitnerInstitute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TUM, Munich, Germany.
Roland RadInstitute of Molecular Oncology and Functional Genomics, School of Medicine and Health, TUM, Munich, Germany.ORCID 0000-0002-6849-9659
Katja SteigerComparative Experimental Pathology, School of Medicine and Health, TUM, Munich, Germany.ORCID 0000-0002-7269-5433
Annette OxeniusInstitute of Microbiology, ETH Zürich, Zürich, Switzerland.ORCID 0000-0002-2079-2354
Wan-Lin LoDepartment of Pathology, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-9074-6847
Victoria KlepschInstitute of Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0003-4146-4664
Gottfried BaierInstitute of Cell Genetics, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0002-2085-8325
Bernhard HolzmannDepartment of Surgery, School of Medicine and Health, TUM, Munich, Germany.
Mala K MainiInstitute of Pathology, School of Medicine and Health, TUM, Munich, Germany.ORCID 0000-0001-6384-1462
Ron HeerenInstitute of Multimodal Imaging, University of Maastricht, Maastricht, The Netherlands.ORCID 0000-0002-6533-7179
Peter J MurrayMax Planck Institute of Biochemistry, Martinsried, Munich, Germany.ORCID 0000-0001-6329-9802
Robert ThimmeThird Department of Medicine, University Hospital Freiburg, Freiburg, Germany.ORCID 0000-0003-1417-4135
Carl HerrmannHealth Data Science Unit, Biomedical Genomics Group, Bioquant, Faculty of Medicine Heidelberg, Heidelberg, Germany.ORCID 0000-0003-4989-4722
Ulrike ProtzerInstitute of Immunology and Animal Physiology, School of Life Science, TUM, Munich, Germany.ORCID 0000-0002-9421-1911
Jan P BöttcherInstitute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.ORCID 0000-0002-8163-8107
Dietmar ZehnInstitute of Immunology and Animal Physiology, School of Life Science, TUM, Munich, Germany.ORCID 0000-0003-1393-8527
Dirk WohlleberInstitute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.ORCID 0000-0003-3861-5150
Georg M LauerDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-9792-4271
Maike HofmannThird Department of Medicine, University Hospital Freiburg, Freiburg, Germany.ORCID 0000-0001-8410-8833
Souphalone LuangsayRoche Pharmaceutical Research and Early Development (pRED), Roche Innovation Center Basel, Basel, Switzerland.
Percy A KnolleInstitute of Molecular Immunology, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany. percy.knolle@tum.de.ORCID 0000-0003-2983-0414
Funding
Unmasking the Immunomodulatory Roles of CD7 SignalingR01AI175301 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Wan-Lin Lo · 2023 to 2026
$2.2MNIAID NIH HHS R01 AI175301
Abstract
Chronic hepatitis B virus (HBV) infection affects 300 million patients worldwide
Indexed as
CD8-Positive T-LymphocytesHepatitis B, ChronicLiverAnimalsCyclic AMP-Dependent Protein KinasesCyclic AMP Response Element ModulatorHepatitis B virusHepatocytesHumansLymphocyte ActivationMaleMicePhosphorylationSignal TransductionCREM protein, humanCrem protein, mouseCyclic AMP-Dependent Protein KinasesCyclic AMP Response Element Modulator
Identifiers
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.