ArticleNature2024
Interferon subverts an AHR-JUN axis to promote CXCL13
Erratum issuedAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 63 papers.
0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed.
- Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026Review
- [Role of AHR-mediated histone acetylation at FOXP3 in Tfr cell differentiation in systemic lupus erythematosus].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Embryonic Phase Transition/Separation on Hepatic Liquid Crystal Droplets Is Essential for Liver Development.Biology · 2026Article
- Aryl hydrocarbon receptor pharmacology-mechanisms, ligands, and therapeutic potential.Pharmacological reviews · 2026Review
- Type I interferons enhance B cell activation and promote differentiation of double negative 2 cells in SLE.Lupus science & medicine · 2026Article
- The Therapeutic Effect of Tapinarof on In Vitro Cutaneous Lupus-like Keratinocyte Model.International journal of molecular sciences · 2026Article
- Auto-loaded polydopamine-M2 exosomes as an antioxidative nanoscavenger for lupus erythematosus therapy.Materials today. Bio · 2026Article
- Dock2 Protects Colitis by Facilitating Akkermansia Colonization via Suppressing IL-22-Reg3 Activity.Inflammation · 2026Article
- Targeting JAK/STAT signalling with cold atmospheric plasma: a potential therapy for systemic lupus erythematosus.Expert reviews in molecular medicine · 2026Review
- Microbial metabolite oxindole curbs acute lung injury by suppressing CXCL13.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Proceedings of the 2Mediterranean journal of rheumatology · 2026Article
- The aryl hydrocarbon receptor (AHR) drives human leukocyte antigen (HLA)-II expression in human melanoma.Journal of experimental & clinical cancer research : CR · 2026Article
- Longitudinal peripheral blood multi-omic profiling in seropositive individuals identifies immune endotypes and predictive models for future rheumatoid arthritis conversion.medRxiv : the preprint server for health sciences · 2026Article
- The CNS Meninges and the Synovial Joint: Parallel Immunological Structures in Autoimmune Disease.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Low-dose IL-2 Ameliorates Experimental Autoimmune Myasthenia Gravis in Rats by Restoring the CD4-positive Helper T-cell Balance Via the JAK/STAT5 Pathway.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026Article
- ALDH3A1-dependent Nrf2/HO-1/GPX4 pathway supports AHR as a promising therapeutic target for ferroptosis and promotes imperatorin-mediated lung protection.Cell death discovery · 2026Article
- Integrated multi-omics profiling identifies aging-related molecular signatures and convergent interferon signaling in systemic lupus erythematosus.Frontiers in immunology · 2026Article
- The landscape of cellular immune alteration in systemic lupus erythematosus.Frontiers in immunology · 2026Review
- AhR agonist Ficz modulates T follicular helper cells and ameliorates skin fibrosis in a bleomycin-induced SSc mouse model.Journal of scleroderma and related disorders · 2026Article
- High baseline CD317 expression on T cells predicts favorable anifrolumab response in systemic lupus erythematosus.Frontiers in immunology · 2026Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
36 authors.
Calvin Law *Department of Biochemistry and Molecular Genetics, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-6784-0085
Vanessa Sue Wacleche *Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Ye Cao *Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Arundhati PillaiDepartment of Biochemistry and Molecular Genetics, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-7234-8255
John SowerbyDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Brandon HancockDepartment of Biochemistry and Molecular Genetics, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Alice HorisbergerDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-3732-8662
Sabrina BraceroDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Viktoriya SkidanovaDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Zhihan LiDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Ifeoluwakiisi AdejoorinDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-8967-5896
Eilish DillonDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0009-0007-6070-5976
Isaac J BenqueDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Diana Pena NunezDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Daimon P SimmonsDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Joshua KeeganDepartment of Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Lin ChenDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-5072-4152
Tina BakerAstraZeneca, Gaithersburg, MD, USA.
Phillip Z BrohawnAstraZeneca, Gaithersburg, MD, USA.
Hussein Al-MossawiAstraZeneca, Late Respiratory and Immunology, Cambridge, UK.
Ling-Yang HaoDiscovery Immunology, Janssen Research & Development, Spring House, PA, USA.
Brian JonesDiscovery Immunology, Janssen Research & Development, Spring House, PA, USA.
Navin RaoDiscovery Immunology, Janssen Research & Development, Spring House, PA, USA.
Yujie QuMerck & Co., Inc., Rahway, NJ, USA.
Stephen E AlvesMerck & Co., Inc., Rahway, NJ, USA.
Accelerating Medicines Partnership: RA/SLE Network
A Helena JonssonDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-9558-2474
Katharina S ShawDepartment of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Ruth Ann VleugelsDepartment of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Elena MassarottiDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Karen H CostenbaderDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Michael B BrennerDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-6202-8445
James A LedererDepartment of Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-6445-252X
Judd F HultquistDivision of Infectious Diseases, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-6424-4280
Jaehyuk ChoiDepartment of Biochemistry and Molecular Genetics, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. jaehyuk.choi@northwestern.edu.ORCID 0000-0003-2379-2226
Deepak A RaoDivision of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. darao@bwh.harvard.edu.ORCID 0000-0001-9672-7746
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9MVirology and Immunology Technology CoreP30AI117943 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Richard D'Aquila, Brian Mustanski · 2015 to 2026
$38.4MProject 3U54AI170792 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nevan J Krogan · 2022 to 2026
$35.7MJoint Biology Consortium Resource-based CenterP30AR070253 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic, Jeffrey Andrew Sparks · 2016 to 2026
$9.4MNorthwestern University Skin Disease Research Center Resource-based CenterP30AR075049 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Irina Budunova · 2019 to 2026
$6.6MTurning off HIV White Noise: Switching from Long-Lived to Short-Lived ReservoirR01AI176599 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Elena Martinelli · 2023 to 2026
$4.7MNewly Identified T Peripheral Helper (Tph) Cells in Rheumatoid ArthritisR01AR073290 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI BRENNER, MICHAEL B. · 2018 to 2022
$2.6MIdentifying Mechanisms Governing T Cell DiversityDP2AI136599 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHOI, JAEHYUK · 2017 to 2017
$2.4MDeciphering the Role of CPSF6 in HIV InfectionR01AI165236 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HULTQUIST, JUDD F · 2021 to 2025
$2.0MRegulation of T helper cell functions by aryl hydrocarbon receptorR01AR078769 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI RAO, DEEPAK ANGARA · 2021 to 2025
$1.9MMolecular control of CD4 T cell ability to help B cellsK08AR072791 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI RAO, DEEPAK ANGARA · 2018 to 2022
$764kElucidating transcriptional and epigenetic regulators of aggressive cutaneous T cell lymphomaF31CA268839 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LAW, CALVIN YUEN YEE · 2022 to 2023
$85kNCI NIH HHS F31 CA268839NCI NIH HHS P30 CA060553NIAID NIH HHS DP2 AI136599NIAID NIH HHS P30 AI117943NIAID NIH HHS R01 AI165236NIAID NIH HHS R01 AI176599NIAID NIH HHS U54 AI170792NIAMS NIH HHS K08 AR072791NIAMS NIH HHS P30 AR070253NIAMS NIH HHS P30 AR075049NIAMS NIH HHS R01 AR073290NIAMS NIH HHS R01 AR078769
Abstract
Systemic lupus erythematosus (SLE) is prototypical autoimmune disease driven by pathological T cell-B cell interactions
Indexed as
Basic Helix-Loop-Helix ProteinsCD4-Positive T-LymphocytesChemokine CXCL13Interferon Type ILupus Erythematosus, SystemicProto-Oncogene Proteins c-junReceptors, Aryl HydrocarbonAntigens, CDCell DifferentiationEpigenomicsFemaleGene Expression ProfilingHumansInducible T-Cell Co-Stimulator ProteinInterleukin-22MaleAHR protein, humanAntigens, CDBasic Helix-Loop-Helix ProteinsCD96 antigenChemokine CXCL13CXCL13 protein, humanICOS protein, humanIL22 protein, humanInducible T-Cell Co-Stimulator ProteinInterferon Type IInterleukin-22JUN protein, humanPDCD1 protein, humanProgrammed Cell Death 1 ReceptorProto-Oncogene Proteins c-junReceptors, Aryl Hydrocarbon
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.