ArticleNature2024
A maternal brain hormone that builds bone.
Registry-linked trialAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04614714 (Nicotinamide Riboside and Milk Production in the NICU), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT04614714 phase2 / phase3not yet recruitingnot on this mapstarted 2026, after this paper: background citation
Nicotinamide Riboside and Milk Production in the NICU
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pregnancy and Lactation Associated Osteoporosis: A Systematic Review.Calcified tissue international · 2026Pooled it
- Skeletal stem and progenitor cell niche organization, regulation and repair.Reviews in endocrine & metabolic disorders · 2026Review
- Screening and identification of genes for cell autonomous sex identity in chicken somatic cells.Poultry science · 2026Article
- Hypothalamic prolactin receptorNature communications · 2026Article
- Advancing Prevention and Treatment of Ankle Osteoarthritis: A Translational Clinical Roadmap from the 2026 AOFAS/Arthritis Foundation Ankle Arthritis Think Tank.Foot & ankle orthopaedics · 2026Review
- Hypothalamic regulation of energy homeostasis: Quo vadis.Reviews in endocrine & metabolic disorders · 2026Review
- Regional heterogeneity in phenotypic and genetic associations between bone and brain in humans.Nature communications · 2026Article
- Membrane-initiated estrogen receptor-α signaling in the hypothalamus regulates trabecular bone in femur in female mice.The Journal of endocrinology · 2026Article
- IGF-1 and insulin receptors in LepRb neurons jointly regulate body growth, bone mass, reproduction, and metabolism.Molecular metabolism · 2026Article
- Neural regulation of bone: from central neural circuits to peripheral innervation of the skeletal stem cell niche.Bone research · 2026Review
- C-Jun NH2-terminal kinase inhibitor bentamapimod prevents RANKL-mediated osteoclastogenesis and ovariectomy-induced osteoporosis.In vitro cellular & developmental biology. Animal · 2026Article
- Does hypothalamic CCN3 hypersecretion confer postpartum mood disorder risk?Translational psychiatry · 2026Review
- Cell Supported Single Membrane Technique for the Treatment of Large Bone Defects: Depletion of CD8Cells · 2026Article
- Estrogen signaling in PDGFRα+ cells positively regulates cortical bone metabolism via IGFBP5 in female mice.JBMR plus · 2026Article
- Advances in the regulation of bone metabolism by central nuclei: a new perspective on the brain-bone axis.Frontiers in neuroscience · 2026Review
- A cellular basis for heightened gut sensitivity in females.Science (New York, N.Y.) · 2025Article
- Swiprosin-1 Negatively Regulates Osteoclast Differentiation and Bone Resorption via Akt/MAPK/NF-κB Pathway and αvβ3 Integrin-Dependent Signaling.International journal of molecular sciences · 2025Article
- HydroWrap for T2DM-Related Fractures: A smart HBioactive materials · 2025Article
- Dynamic changes in Ccn3 expression across the limbic forebrain through the mouse estrous cycle and during lactation.Journal of neuroendocrinology · 2025Article
- Mesenchymal Stromal Cell-Derived Extracellular Vesicles as a Therapeutic Treatment for Osteosarcopenia: Crosstalk Among Neurons, Muscle, and Bone.International journal of molecular sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Muriel E Babey *Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Francisco, San Francisco, CA, USA.
William C Krause *Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.
Kun ChenDepartment of Orthopaedic Surgery, University of California, Davis, Sacramento, CA, USA.ORCID 0000-0003-0507-7640
Candice B HerberDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.
Zsofia TorokDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-6298-9940
Joni NikkanenDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.
Ruben RodriguezDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.
Xiao ZhangDepartment of Medicine, Washington University, St Louis, MO, USA.
Fernanda Castro-NavarroDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.
Yuting WangInstitute for Stem Cell Biology and Regenerative Medicine and Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Erika E WheelerDepartment of Orthopaedic Surgery, University of California, Davis, Sacramento, CA, USA.ORCID 0000-0002-0851-3535
Saul VilledaDepartment of Anatomy, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-2726-9582
J Kent LeachDepartment of Orthopaedic Surgery, University of California, Davis, Sacramento, CA, USA.ORCID 0000-0002-1673-3335
Nancy E LaneDepartment of Medicine, Division of Rheumatology, University of California, Davis, Sacramento, CA, USA.
Erica L SchellerDepartment of Medicine, Washington University, St Louis, MO, USA.
Charles K F ChanInstitute for Stem Cell Biology and Regenerative Medicine and Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Thomas H AmbrosiDepartment of Orthopaedic Surgery, University of California, Davis, Sacramento, CA, USA. thambrosi@ucdavis.edu.
Holly A IngrahamDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA. holly.ingraham@ucsf.edu.ORCID 0000-0001-6739-2967
Funding
UCSF IRACDA Scholars ProgramK12GM081266 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Raymond M. Esquerra, HOLLY A. INGRAHAM · 2007 to 2026
$19.4MSkeletal Biology and Biomechanics (SBB) CoreP30AR075055 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Wenhan Chang · 2019 to 2026
$7.1MResource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI Simon Yue-Cheong Tang · 2019 to 2026
$6.8MOrphan Nuclear Receptors in Development and PhysiologyR01DK063592 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI INGRAHAM, HOLLY A. · 2003 to 2013
$3.5MDissecting a hormone-responsive processor for female activity and repetitive behaviorR01DK121657 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI INGRAHAM, HOLLY A. · 2020 to 2024
$2.9MThe Study of Muscle, Mobility and Aging with Knee OAR01AG070647 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Nancy E Lane · 2021 to 2026
$2.5MArcuate ERa Signaling in Central Control of Female Bone MetabolismR01AG062331 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI INGRAHAM, HOLLY A. · 2019 to 2023
$2.3MRole of exercise-induced blood factors in rejuvenating the aged brainR01AG067740 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VILLEDA, SAUL A · 2020 to 2024
$2.0MSarm1 and neural regulation of boneR01DK132073 · NIDDK · WASHINGTON UNIVERSITY · PI Erica Lynn Scheller · 2023 to 2026
$1.6MReversing Skeletal Aging by Restoring Functional Skeletal Stem Cell DiversityR00AG066963 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI AMBROSI, THOMAS HANS · 2023 to 2025
$742kDetermining the Role of Brain-Derived CCN3 in Bone and Marrow Fat MetabolismK08DK133674 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Muriel Babey · 2024 to 2026
$513kMarrow adipocytes modify the neural regulation of boneR56AR081251 · NIAMS · WASHINGTON UNIVERSITY · PI SCHELLER, ERICA LYNN · 2022 to 2022
$341kNIAMS NIH HHS P30 AR074992NIAMS NIH HHS P30 AR075055NIAMS NIH HHS R56 AR081251NIA NIH HHS K01 AG065916NIA NIH HHS K99 AG066963NIA NIH HHS R00 AG066963NIA NIH HHS R01 AG062331NIA NIH HHS R01 AG067740NIA NIH HHS R01 AG070647NIDDK NIH HHS K08 DK133674NIDDK NIH HHS K99 DK129763NIDDK NIH HHS R01 DK063592NIDDK NIH HHS R01 DK121657NIDDK NIH HHS R01 DK132073NIGMS NIH HHS K12 GM081266
Abstract
In lactating mothers, the high calcium (Ca
Indexed as
Bone and BonesBone DensityBrainHormonesMothersNephroblastoma Overexpressed ProteinOsteogenesisAdolescentAgingAnimalsArcuate Nucleus of HypothalamusBone RemodelingBone ResorptionCalciumFemaleHumansCalciumCCN3 protein, humanCcn3 protein, mouseHormonesKISS1 protein, humanKiss1 protein, mouseKisspeptinsNephroblastoma Overexpressed Protein
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
NCT04614714ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.