Evidence map›Paper›PMID 38987558›Full record

ArticleNature communications2024

Developmental trajectories of EEG aperiodic and periodic components in children 2-44 months of age.

Carol L Wilkinson, Lisa D Yankowitz, Jerry Y Chao, Rodrigo Gutiérrez, Jeff L Rhoades, Shlomo Shinnar, Patrick L Purdon, Charles A Nelson

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

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  4. Cortical Network Overconnectivity Relates to Sensory, Cognitive, and Social Dimensions in Young Children With Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Carol L WilkinsonDivision of Developmental Medicine, Boston Children's Hospital, Boston, MA, USA. carol.wilkinson@childrens.harvard.edu.ORCID 0000-0002-4694-8564
Lisa D YankowitzDivision of Developmental Medicine, Boston Children's Hospital, Boston, MA, USA.
Jerry Y ChaoDepartment of Anesthesiology, Montefiore Medical Center, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID 0000-0001-8666-7583
Rodrigo GutiérrezDepartamento de Anestesia y Medicina Perioperatoria, Hospital Clínico de la Universidad de Chile, Santiago, Chile.
Jeff L RhoadesDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-5077-2533
Shlomo ShinnarThe Saul R. Korey Department of Neurology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA.
Patrick L PurdonDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.
Charles A NelsonDivision of Developmental Medicine, Boston Children's Hospital, Boston, MA, USA.

Funding

CTSA Administrative Supplement for Informatics Core: A novel AI/ML system to predict respiratory failure and ARDS in Covid-19 patientsUL1TR002556 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, KIM, MIMI Y · 2018 to 2022
$26.7M
The Development of Face ProcessingR01MH078829 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI Michelle A Bosquet Enlow · 2006 to 2026
$14.8M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
Neurobehavioral Research on Infants at Risk for SLI and AutismR01DC010290 · NIDCD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI NELSON, CHARLES ALEXANDER, TAGER-FLUSBERG, HELEN · 2009 to 2020
$7.5M
Institutional Career Development CoreKL2TR002558 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MARANTZ, PAUL R · 2018 to 2022
$2.7M
Translational Post-doctoral Training in NeurodevelopmentT32MH112510 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI DAVID C GLAHN, CHARLES Alexander NELSON · 2017 to 2026
$2.6M
Neural Markers of Language Development in Fragile X Syndrome and Autism Spectrum DisorderK23DC017983 · NIDCD · BOSTON CHILDREN'S HOSPITAL · PI WILKINSON, CAROL LEE · 2020 to 2024
$859k
Analgesic-Behavioral and Neurophysiological Correlates of Opioid-Sparing Spinal Anesthesia Compared to General Anesthesia in Human InfantsK23DA057499 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI CHAO, JERRY Y · 2023 to 2025
$587k
Molecular mechanisms of aging in the intrinsic laryngeal musclesR03DC007983 · NIDCD · UNIVERSITY OF KENTUCKY · PI MCMULLEN, COLLEEN A · 2006 to 2009
$249k
NCATS NIH HHS KL2 TR002558NCATS NIH HHS UL1 TR002556NICHD NIH HHS P50 HD105351NIDA NIH HHS K23 DA057499NIDA NIH HHS L70 DA057081NIDCD NIH HHS K23 DC017983NIDCD NIH HHS R01 DC010290NIDCD NIH HHS R03 DC007983NIMH NIH HHS R01 MH078829NIMH NIH HHS T32 MH112510U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) KL2TR002558U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR002556U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH078829U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) T32MH112510U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) K23DC07983U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) R01-DC01290U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) K23DA057499
6 · The paper itself

Abstract

The development of neural circuits has long-lasting effects on brain function, yet our understanding of early circuit development in humans remains limited. Here, periodic EEG power features and aperiodic components were examined from longitudinal EEGs collected from 592 healthy 2-44 month-old infants, revealing age-dependent nonlinear changes suggestive of distinct milestones in early brain maturation. Developmental changes in periodic peaks include (1) the presence and then absence of a 9-10 Hz alpha peak between 2-6 months, (2) nonlinear changes in high beta peaks (20-30 Hz) between 4-18 months, and (3) the emergence of a low beta peak (12-20 Hz) in some infants after six months of age. We hypothesized that the emergence of the low beta peak may reflect maturation of thalamocortical network development. Infant anesthesia studies observe that GABA-modulating anesthetics do not induce thalamocortical mediated frontal alpha coherence until 10-12 months of age. Using a small cohort of infants (n = 23) with EEG before and during GABA-modulating anesthesia, we provide preliminary evidence that infants with a low beta peak have higher anesthesia-induced alpha coherence compared to those without a low beta peak.

Indexed as

BrainElectroencephalographyAlpha RhythmAnesthesiaBeta RhythmChild DevelopmentChild, PreschoolFemaleHumansInfantLongitudinal StudiesMaleThalamus

Identifiers

PMID38987558
PMCPMC11237135

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.