Evidence map›Paper›PMID 38987508›Full record

ArticleDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences2024

Toxicological effect of acetaminophen, metamizole, and nimesulide cocktail on early development of zebrafish.

Wellington Fernandes de Carvalho, Ednalva de Souza Pereira Lima, Whocely Victor de Castro, Ralph Gruppi Thomé, Hélio Batista Santos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wellington Fernandes de CarvalhoLaboratório de Processamento de Tecidos (Laprotec), Universidade Federal de São João del Rei, Campus Centro Oeste Dona Lindu, Avenida Sebastião Gonçalves Coelho, Divinópolis, MG, CEP, 40035501296, Brazil.ORCID http://orcid.org/0009-0003-5734-1500
Ednalva de Souza Pereira LimaLaboratório de Controle de Qualidade e Farmacocinética, Universidade Federal de São João del Rei, Campus Centro Oeste Dona Lindu, Avenida Sebastião Gonçalves Coelho, Divinópolis, MG, CEP, 40035501296, Brazil.ORCID http://orcid.org/0009-0001-3182-6935
Whocely Victor de CastroLaboratório de Controle de Qualidade e Farmacocinética, Universidade Federal de São João del Rei, Campus Centro Oeste Dona Lindu, Avenida Sebastião Gonçalves Coelho, Divinópolis, MG, CEP, 40035501296, Brazil.ORCID http://orcid.org/0000-0002-8354-1843
Ralph Gruppi ThoméLaboratório de Processamento de Tecidos (Laprotec), Universidade Federal de São João del Rei, Campus Centro Oeste Dona Lindu, Avenida Sebastião Gonçalves Coelho, Divinópolis, MG, CEP, 40035501296, Brazil.ORCID http://orcid.org/0000-0002-1779-5036
Hélio Batista SantosLaboratório de Processamento de Tecidos (Laprotec), Universidade Federal de São João del Rei, Campus Centro Oeste Dona Lindu, Avenida Sebastião Gonçalves Coelho, Divinópolis, MG, CEP, 40035501296, Brazil. hbsantos@ufsj.edu.br.ORCID http://orcid.org/0000-0001-6813-8522

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral countries' most incorrectly discarded medicines are acetaminophen (ACM), metamizole (MTZ), and nimesulide (NMS). These xenobiotics easily reach the aquatic environment; such contamination is very important for the health of humans and other species, yet little explored.

objectivesTo evaluate the cocktail effect of ACM, MTZ, and NMS during zebrafish's initial development.

methodsZebrafish embryos 6-8 h post-fertilization (hpf) were exposed to different concentrations of ACM, MTZ, and NMS, separately, to obtain the 50% lethal concentrations (LC

resultsThe LC

conclusionThis study's findings suggest the cocktail of ACM, MTZ, and NMS may be hazardous to aquatic organisms in case of environmental contamination.

Indexed as

AcetaminophenDipyroneEmbryo, NonmammalianSulfonamidesZebrafishAnimalsAnti-Inflammatory Agents, Non-SteroidalDose-Response Relationship, DrugEmbryonic DevelopmentLethal Dose 50Water Pollutants, ChemicalAcetaminophenAnti-Inflammatory Agents, Non-SteroidalDipyronenimesulideSulfonamidesWater Pollutants, ChemicalDipyrone and paracetamolEmbryonic developmentEmerging pollutantsPharmaceuticals productsPigmentationTeratogenic effects

Identifiers

PMID38987508
PMCPMC11555034

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.