Evidence map›Paper›PMID 38987507›Full record

ArticleSleep & breathing = Schlaf & Atmung2024

Physiologic and anatomic determinants of hyoid motion during drug-induced sleep endoscopy.

Manan H Parekh, Eric Thuler, Vasiliki Triantafillou, Everett Seay, Chandra Sehgal, Susan Schultz, Brendan T Keenan, Alan R Schwartz, Raj C Dedhia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Mandibular advancement devices in obstructive sleep apnea: diagnostic predictors for treatment response and clinical implications : A retrospective pilot cohort study.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Manan H ParekhDepartment of Otorhinolaryngology - Head & Neck Surgery, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA. manan.parekh611@gmail.com.ORCID 0000-0001-7528-6910
Eric ThulerDepartment of Otorhinolaryngology - Head & Neck Surgery, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Vasiliki TriantafillouDepartment of Otorhinolaryngology - Head & Neck Surgery, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Everett SeayDepartment of Otorhinolaryngology - Head & Neck Surgery, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Chandra SehgalDepartment of Radiology, University of Pennsylvania, Philadelphia, USA.
Susan SchultzDepartment of Radiology, University of Pennsylvania, Philadelphia, USA.
Brendan T KeenanDivision of Sleep Medicine/Department of Medicine, University of Pennsylvania, Philadelphia, USA.
Alan R SchwartzDepartment of Otorhinolaryngology - Head & Neck Surgery, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Raj C DedhiaDepartment of Otorhinolaryngology - Head & Neck Surgery, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.

Funding

Lingual muscle control of upper airway patency in obstructive sleep apneaR01HL144859 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI DEDHIA, RAJ C., SCHWARTZ, ALAN R. · 2019 to 2023
$3.9M
Foundation for the National Institutes of Health 1R01HL144859-04NHLBI NIH HHS R01 HL144859
6 · The paper itself

Abstract

purposeTo examine factors accounting for differences in hyoid motion during obstructive breathing events amongst obstructive sleep apnea (OSA) patients.

methodsThis was a prospective cohort study from June 2022 to October 2022. Patients with OSA undergoing evaluation for PAP alternative therapies with drug-induced sleep endoscopy with positive airway pressure titration (DISE-PAP). All patients underwent DISE-PAP and concurrent hyoid-focused ultrasound. DISE-PAP enabled measurement of airway physiology (flow, respiratory effort) and airway collapsibility (pharyngeal opening pressure, PhOP). Hyoid-ultrasound enabled hyoid bone movement during obstructive breathing. Respiratory effort was measured using a retro-epiglottic pressure-sensitive catheter. Hyoid position was measured using a standardized, awake, CT protocol. Regression analyses adjusted for age, race, sex, and BMI were performed to associate indices of respiratory effort and CT data with hyoid motion.

resultsOn average, the 26 patients in this cohort were older (63.9 ± 10.5 years), male (69%), overweight (29.6 ± 3.99 kg/m

conclusionOur data demonstrate that greater respiratory effort, higher hyoid position, and higher airway collapsibility, but not airflow, are associated with greater hyoid motion during obstructive breathing in DISE. These findings suggest that downward hyoid movement represents a compensatory response to upper airway obstruction. Further studies should investigate the vectors of hyoid motion to better understand its role in sleep-related airway collapse.

Indexed as

Hyoid BoneSleep Apnea, ObstructiveAgedCohort StudiesContinuous Positive Airway PressureEndoscopyFemaleHumansMaleMiddle AgedPolysomnographyProspective StudiesDrug-induced sleep endoscopyHyoidObstructive sleep apnea

Identifiers

PMID38987507
PMCPMC11450060

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.