ArticleNature communications2024
Robust trigger wave speed in Xenopus cytoplasmic extracts.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- How does cytoplasmic crowding affect reaction rates?Molecular cell · 2026Review
- Synthetic Cell-Based Approaches to Dissect Autonomous Cellular Oscillators: Recent Applications on the Cell Cycle.Advances in experimental medicine and biology · 2026Review
- Geometrical compartmentalization of trigger waves.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Spatial heterogeneity accelerates phase-to-trigger wave transitions in frog egg extracts.Nature communications · 2024Article
- Viscosity-dependent control of protein synthesis and degradation.Nature communications · 2024Article
- Mitotic waves in frog egg extracts: Transition from phase waves to trigger waves.bioRxiv : the preprint server for biology · 2024Article
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5 authors.
Funding
Abstract
Self-regenerating trigger waves can spread rapidly through the crowded cytoplasm without diminishing in amplitude or speed, providing consistent, reliable, long-range communication. The macromolecular concentration of the cytoplasm varies in response to physiological and environmental fluctuations, raising the question of how or if trigger waves can robustly operate in the face of such fluctuations. Using Xenopus extracts, we find that mitotic and apoptotic trigger wave speeds are remarkably invariant. We derive a model that accounts for this robustness and for the eventual slowing at extremely high and low cytoplasmic concentrations. The model implies that the positive and negative effects of cytoplasmic concentration (increased reactant concentration vs. increased viscosity) are nearly precisely balanced. Accordingly, artificially maintaining a constant cytoplasmic viscosity during dilution abrogates this robustness. The robustness in trigger wave speeds may contribute to the reliability of the extremely rapid embryonic cell cycle.
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Registered trials
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