Evidence map›Paper›PMID 38987190›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Melanoma Differentiation-associated Gene 5-Positive Rapidly Progressive Interstitial Lung Disease Successfully Treated with Tofacitinib.

Kunika Shimizu, Ryo Yanai, Kie Yamamoto, Yuta Michizu, Yuzo Ikari, Nobuyuki Yajima

Abstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kunika ShimizuDivision of Rheumatology, Department of Medicine, Showa University School of Medicine, Japan.
Ryo YanaiDivision of Rheumatology, Department of Medicine, Showa University School of Medicine, Japan.
Kie YamamotoDivision of Rheumatology, Department of Medicine, Showa University School of Medicine, Japan.
Yuta MichizuDivision of Rheumatology, Department of Medicine, Showa University School of Medicine, Japan.
Yuzo IkariDivision of Rheumatology, Department of Medicine, Showa University School of Medicine, Japan.
Nobuyuki YajimaDivision of Rheumatology, Department of Medicine, Showa University School of Medicine, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-melanoma differentiation-associated gene 5 (MDA-5) antibody-positive dermatomyositis is associated with rapidly progressive interstitial lung disease (RP-ILD). We encountered a man in his 40s who presented with a history of a fever and dry cough. Based on laboratory tests and computed tomography scans of his chest, he was diagnosed with anti-MDA-5 antibody-positive dermatomyositis with RP-ILD refractory to antimicrobial agents. Although the patient was treated with glucocorticoids, calcineurin inhibitors, intravenous cyclophosphamide, and plasma exchange, ventilatory management was still required. The patient survived additional therapy with tofacitinib; however, he developed a catheter-related pulmonary embolism as a complication.

Indexed as

Interferon-Induced Helicase, IFIH1Lung Diseases, InterstitialPiperidinesProtein Kinase InhibitorsPyrimidinesPyrrolesAdultAutoantibodiesDermatomyositisDisease ProgressionHumansMaleTreatment OutcomeAutoantibodiesIFIH1 protein, humanInterferon-Induced Helicase, IFIH1PiperidinesProtein Kinase InhibitorsPyrimidinesPyrrolestofacitinibanti-melanoma differentiation-associated gene 5catheter-related pulmonary embolismdermatomyositisrapidly progressive interstitial lung diseasetofacitinib

Identifiers

PMID38987190
PMCPMC11904449

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.