Evidence map›Paper›PMID 38987180›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Pathogenic TNFRSF13B Variant in an Adult Japanese Patient with Common Variable Immunodeficiency.

Naokazu Nakamura, Ryo Ikunari, Yasuhiro Tanaka, Hiroko Tsunemine, June Takeda, Nobuyoshi Arima

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PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Naokazu NakamuraDepartment of Hematology, Shinko Hospital, Japan.
Ryo IkunariDepartment of Hematology, Shinko Hospital, Japan.
Yasuhiro TanakaDepartment of Hematology, Shinko Hospital, Japan.
Hiroko TsunemineDepartment of Hematology, Shinko Hospital, Japan.
June TakedaDepartment of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Japan.
Nobuyoshi ArimaDepartment of Hematology, Shinko Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Common variable immunodeficiency (CVID) is a primary B cell immunodeficiency disorder. Symptoms do not develop immediately after birth, and patients are often diagnosed in childhood and adulthood. These patients often develop autoimmune diseases and malignant tumors. We herein report a 50-year-old woman with severe hypogammaglobulinemia and recurrent respiratory tract infections who was diagnosed with CVID. Target sequencing showed a TNFRSF13B heterozygous frameshift variant. The patient had many comorbidities, probably caused by a CVID-induced immune imbalance. Physicians who treat adult patients are often unaware of CVID. CVID should be recognized as a differential diagnosis in hypogammaglobulinemia and recurrent infections.

Indexed as

Common Variable ImmunodeficiencyTransmembrane Activator and CAML Interactor ProteinAgammaglobulinemiaDiagnosis, DifferentialEast Asian PeopleFemaleFrameshift MutationHumansJapanMiddle AgedRespiratory Tract InfectionsTNFRSF13B protein, humanTransmembrane Activator and CAML Interactor Proteincommon variable immunodeficiencyhypogammaglobulinemiaprimary immunodeficiency

Identifiers

PMID38987180
PMCPMC11949678

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.