Evidence map›Paper›PMID 38986894›Full record

ArticleBiochimica et biophysica acta. Biomembranes2024

Pathological mutations in the phospholamban cytoplasmic region affect its topology and dynamics modulating the extent of SERCA inhibition.

Daniel K Weber, U Venkateswara Reddy, Seth L Robia, Gianluigi Veglia

Abstract read
In one paragraph

Article in Biochimica et biophysica acta. Biomembranes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Membrane Topology and Oligomerization of Peptaibols by Solid-State NMR Spectroscopy.Journal of peptide science : an official publication of the European Peptide Society · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Genetic landscape of phospholamban cardiomyopathies.Frontiers in cell and developmental biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daniel K WeberDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
U Venkateswara ReddyDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Seth L RobiaDepartment of Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL, USA.
Gianluigi VegliaDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: vegli001@umn.edu.

Funding

Structural Determinants of Calcium Pump RegulationR01HL092321 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI Seth L Robia · 2008 to 2026
$8.9M
New mechanisms of SERCA regulation: Dimerization and MicropeptidesR01HL143816 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI Seth L Robia, Gianluigi Veglia · 2019 to 2026
$3.6M
The NKA Interactome in Health and DiseaseR01HL158649 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI BOSSUYT, JULIE B, ROBIA, SETH L · 2022 to 2025
$2.7M
Structural Basis of Dilated CardiomyopathyR01HL144130 · NHLBI · UNIVERSITY OF MINNESOTA · PI VEGLIA, GIANLUIGI · 2018 to 2021
$1.5M
American Heart Association-American Stroke Association 19POST34420009NHLBI NIH HHS R01 HL092321NHLBI NIH HHS R01 HL143816NHLBI NIH HHS R01 HL144130NHLBI NIH HHS R01 HL158649
6 · The paper itself

Abstract

Phospholamban (PLN) is a 52 amino acid regulin that allosterically modulates the activity of the sarco(endo)plasmic reticulum Ca

Indexed as

Calcium-Binding ProteinsSarcoplasmic Reticulum Calcium-Transporting ATPasesAnimalsBinding SitesCalciumCytoplasmHumansMutationPhospholambanPhosphorylationProtein BindingCalciumCalcium-Binding ProteinsPhospholambanSarcoplasmic Reticulum Calcium-Transporting ATPasesCa(2+) transportDilated cardiomyopathyOriented sample solid-state NMRPhospholambanRegulinsSERCA inhibitionStructural topology

Identifiers

PMID38986894
PMCPMC11457527

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.