Evidence map›Paper›PMID 38986847›Full record

ReviewSurvey of ophthalmology

Advances in ophthalmic therapeutic delivery: A comprehensive overview of present and future directions.

Ali Torkashvand, Afshin Izadian, Amir Hajrasouliha

Abstract readReview
In one paragraph

Review in Survey of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ali TorkashvandDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, United States.
Afshin IzadianElectrical and Computer Engineering Technology, Purdue University, West Lafayette, IN, United States.
Amir HajrasoulihaDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, United States. Electronic address: amhajras@iu.edu.

Funding

Gold nanoparticle Neurosensory Epiretinal Implant to Treat Photoreceptor Vision LossR21EY032652 · NEI · INDIANA UNIVERSITY INDIANAPOLIS · PI HAJRASOULIHA, AMIR REZA, IZADIAN, AFSHIN · 2022 to 2023
$436k
NEI NIH HHS R21 EY032652
6 · The paper itself

Abstract

Ophthalmic treatment demands precision and consistency in delivering therapeutic agents over extended periods to address many conditions, from common eye disorders to complex diseases. This diversity necessitates a range of delivery strategies, each tailored to specific needs. We delve into various delivery cargos that are pivotal in ophthalmic care. These cargos encompass biodegradable implants that gradually release medication, nonbiodegradable implants for sustained drug delivery, refillable tools allowing flexibility in treatment, hydrogels capable of retaining substances while maintaining ocular comfort, and advanced nanotechnology devices that precisely target eye tissues. Within each cargo category, we explore cutting-edge research-level approaches and FDA-approved methods, providing a thorough overview of the current state of ophthalmic drug delivery. In particular, our focus on nanotechnology reveals the promising potential for gene delivery, cell therapy administration, and the implantation of active devices directly into the retina. These advancements hold the key to more effective, personalized, and minimally- invasive ophthalmic treatments, revolutionizing the field of eye care.

Indexed as

Drug Delivery SystemsEye DiseasesHumansNanotechnologyElectrophoresisEncapsulated cell therapyGene deliveryGene therapyHydrogelImplantsMicroneedleNanoparticlesOphthalmic drug deliveryPort delivery systemRetinal diseaseSuprachoroidal deliverySustained releaseTransscleral delivery

Identifiers

PMID38986847
PMCPMC11392635

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.