Article in Journal of neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
8 authors.
Pietro MazzoniDivision of Movement Disorders, Department of Neurology, The Ohio State University, Columbus, Ohio, United States.ORCID 0000-0002-7367-8811
Mwiza UsheDivision of Movement Disorders, Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, United States.
John R YounceDivision of Movement Disorders, Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, United States.ORCID 0000-0003-4822-9608
Scott A NorrisDivision of Movement Disorders, Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, United States.ORCID 0000-0002-3835-0976
Tamara HersheyDivision of Movement Disorders, Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, United States.
Morvarid KarimiDivision of Movement Disorders, Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, United States.
Samer D TabbalDivision of Movement Disorders, Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, United States.
Joel S PerlmutterDivision of Movement Disorders, Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, United States.ORCID 0000-0003-3263-8917
Funding
INVESTIGATIONS OF DEMENTIA IN PARKINSON DISEASER01NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2011 to 2021
$8.2M
MECHANISMS OF DEEP BRAIN STIMULATIONR01NS041509 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2001 to 2015
$6.8M
PET PROBES FOR IMAGING THE VESICULAR ACETYLCHOLINE TRANSPORTERR01NS075527 · NINDS · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2011 to 2021
$4.9M
VALIDATION OF NEUROIMAGING BIOMARKERS FOR NIGROSTRIATAL NEURONSR01NS058714 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2008 to 2016
$4.4M
Neuroinflammatory Biomarkers for Nigrostriatal InjuryR01NS107281 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2019 to 2023
$3.3M
Neuroimaging of PDE10AR01NS103957 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES, TU, ZHUDE · 2017 to 2021
$3.1M
The Role of Striatal Cholinergic Interneurons in DystoniaR01NS124789 · NINDS · WASHINGTON UNIVERSITY · PI Scott Allen Norris · 2022 to 2026
$3.0M
CARBOXYFULLERENE TREATMENT OF MPTP-INDUCED PARKINSONISMR01NS050425 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2005 to 2009
$2.6M
Investigations of Dementia in Parkinson DiseaseRF1NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2023 to 2023
$2.3M
RESCUE FROM NIGROSTRIATAL INJURYR01NS039913 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2001 to 2003
$1.2M
Prediction of outcomes for deep brain stimulation using multimodal MRIK23NS121630 · NINDS · WASHINGTON UNIVERSITY · PI John Robert Younce · 2022 to 2026
$907k
American Parkinson Disease Association (APDA)HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS039913HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS041509HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS050425HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS058714HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS075321HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS075527HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS103957HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS107281HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS124789NINDS NIH HHS K23 NS121630NINDS NIH HHS R01 NS039913NINDS NIH HHS R01 NS041509NINDS NIH HHS R01 NS050425NINDS NIH HHS R01 NS058714NINDS NIH HHS R01 NS075321NINDS NIH HHS R01 NS075527NINDS NIH HHS R01 NS103957NINDS NIH HHS R01 NS107281NINDS NIH HHS R01 NS124789NINDS NIH HHS RF1 NS075321
6 · The paper itself
Abstract
Bradykinesia is a term describing several manifestations of movement disruption caused by Parkinson's disease (PD), including movement slowing, amplitude reduction, and gradual decrease of speed and amplitude over multiple repetitions of the same movement. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves bradykinesia in patients with PD. We examined the effect of DBS on specific components of bradykinesia when applied at two locations within the STN, using signal processing techniques to identify the time course of amplitude and frequency of repeated hand pronation-supination movements performed by participants with and without PD. Stimulation at either location increased movement amplitude, increased frequency, and decreased variability, though not to the range observed in the control group. Amplitude and frequency showed decrement within trials, which was similar in PD and control groups and did not change with DBS. Decrement across trials, by contrast, differed between PD and control groups, and was reduced by stimulation. We conclude that DBS improves specific aspects of movement that are disrupted by PD, whereas it does not affect short-term decrement that could reflect muscular fatigue.
Indexed as
Deep Brain StimulationHypokinesiaParkinson DiseaseSubthalamic NucleusAgedFemaleHumansMaleMiddle AgedMovementDBSkinematicsmotor controlmovementwearable sensors
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Differential components of bradykinesia in Parkinson's disease revealed by deep brain stimulation. · full record | OpenQuestion