ArticleScience advances2024
Weakly ionized gold nanoparticles amplify immunoassays for ultrasensitive point-of-care sensors.
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- A ultrasensitive immunoassay based on weakly charged AuNPs orientated antibody for triazophos detection in vegetables.Mikrochimica acta · 2026Article
- Coordination-Driven Metal-Phenolic Network Complexes for Programmable Colorimetric Signal Transduction and Defined Nano-Bio Interfaces.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- A Novel Microfluidic Strategy for the Fabrication of α-Lactalbumin Nanomicelles Paves a New Path for Antiobesity Technology.Advanced healthcare materials · 2026Article
- Evaluation of a Rapid Lateral Flow Assay for Coccidioidomycosis to Monitor Antibody Levels in Patients Using Fingerstick Capillary Blood.Journal of fungi (Basel, Switzerland) · 2026Article
- Fishnet-like 2D magnetic nanozyme probe enables ultrasensitive bedside immunodiagnosis of bone infection pathogens.Bioactive materials · 2026Article
- Advances in Immunological Methods for the Detection ofSensors (Basel, Switzerland) · 2026Review
- Atomically precise ligand engineering of gold nanoparticles via interphase mass transfer.Nature communications · 2026Article
- Advancing Lateral Flow Detection in CRISPR/Cas12a Systems Through Rational Understanding and Design Strategies of Reporter Interactions.Biosensors · 2025Article
- Rapid On-Site Detection of Zearalenone in Maize Using a Colloidal Gold Immunochromatographic Strip.Biosensors · 2025Article
- Multifunctional Nanobody Fusion Proteins in Immunoassays: Diverse Strategies for Enhanced Analytical Performance.Trends in analytical chemistry : TRAC · 2025Article
- First Report of On-Site Detection of Cucurbit Leaf Crumple Virus by an Optimized RPA-Lateral Flow Assay with an Alternative Endonuclease.International journal of molecular sciences · 2025Article
- Chemically tailored anionic antibiotic adjuvants targeting divalent cations to overcome carbapenem resistance in gram-negative bacteria.Science advances · 2025Article
- Soft bioelectronics embedded with self-confined tetrahedral DNA circuit for high-fidelity chronic wound monitoring.Nature communications · 2025Article
- Early Detection of Multiple Sclerosis Using Spectroscopic Epstein-Barr Virus Biosensors Based on Infection Mechanism Mimicry.Analytical chemistry · 2025Article
- DNAzyme-driven dual-cycle coupled with pregnancy test strip signal transduction for monitoring of Dreissena polymorpha.Mikrochimica acta · 2025Article
- A wearable device for continuous immunoassay-based monitoring of C-peptide in interstitial fluid.Science advances · 2025Article
- Development of sensitive and specific immunochromatographic strips with nanoparticles for rapid detection of flumequine.Food chemistry: X · 2025Article
- Gold nanotriangle-enhanced high-sensitive determination of alpha-fetoprotein via lateral flow immunoassay in serum.Mikrochimica acta · 2025Article
- Colorimetric Biosensors: Advancements in Nanomaterials and Cutting-Edge Detection Strategies.Biosensors · 2025Review
- Self-powered sensing platform based on triboelectric nanogenerators towards intelligent mining industry.Nature communications · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gold nanoparticle-based lateral flow immunoassays (AuNP LFIAs) are widely used point-of-care (POC) sensors for in vitro diagnostics. However, the sensitivity limitation of conventional AuNP LFIAs impedes the detection of trace biomarkers. Several studies have explored the size and shape factors of AuNPs and derivative nanohybrids, showing limited improvements or enhanced sensitivity at the cost of convenience and affordability. Here, we investigated surface chemistry on the sensitivity of AuNP LFIAs. By modifying surface ligands, a surface chemistry strategy involving weakly ionized AuNPs enables ultrasensitive naked-eye LFIAs (~100-fold enhanced sensitivity). We demonstrated how this surface chemistry-amplified immunoassay approach modulates nanointerfacial bindings to promote antibody adsorption and higher activity of adsorbed antibodies. This surface chemistry design eliminates complex nanosynthesis, auxiliary devices, or additional reagents while efficiently improving sensitivity with advantages: simplified fabrication process, excellent reproducibility and reliability, and ultrasensitivity toward various biomarkers. The surface chemistry using weakly ionized AuNPs represents a versatile approach for sensitizing POC sensors.
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